Sigma-Aldrich/Flurbiprofen/PHR1499-500MG/500MG

• CAS Number 5104-49-4

• Linear Formula C₆H₅C₆H₃(F)CH(CH₃)CO₂H

• Molecular Weight 244.26

•  EC Number 225-827-6

•  MDL number MFCD00079303

•  PubChem Substance ID 329823420

Properties:

Description:

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDE 34:2009 (AClass Cert AR-1470).

Biochem/physiol Actions

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3047 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety:

Symbol 

  GHS06