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Abnova/ABL1 (phospho Y245) polyclonal antibody/1kit/PAB7918
  • Abnova/ABL1 (phospho Y245) polyclonal antibody/1kit/PAB7918

Abnova/ABL1 (phospho Y245) polyclonal antibody/1kit/PAB7918

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貨號(hào): PAB7918
品牌: Abnova
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  • 詳情
  • 使用說(shuō)明
  • 常見(jiàn)問(wèn)題
      • Specification
      • Gene Info
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Rabbit polyclonal antibody raised against synthetic phosphopeptide of ABL1.
      • Immunogen:
      • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y245 of human ABL1.
      • Host:
      • Rabbit
      • Reactivity:
      • Human, Mouse, Rat
      • Specificity:
      • This peptide sequence has high homology to the conserved site in rat and mouse c-Abl, as well as in viral Abl and BCR-Abl fusion protein.
      • Form:
      • Liquid
      • Quality Control Testing:
      • Antibody Reactive Against Synthetic Peptide.
      • Recommend Usage:
      • ELISA (1:2000)Western Blot (1:1000)The optimal working dilution should be determined by the end user.
      • Storage Buffer:
      • In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
      • Storage Instruction:
      • Store at -20°C.Aliquot to avoid repeated freezing and thawing.
      • Note:
      • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
      • Datasheet:
      • PDF DownloadDownload
      • Publication Reference
      • 1.
      • Autoinhibition of c-Abl.Pluk H, Dorey K, Superti-Furga G.Cell. 2002 Jan 25;108(2):247-59.
      • 2.
      • c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines.Brasher BB, Van Etten RA.J Biol Chem. 2000 Nov 10;275(45):35631-7.
      • 3.
      • Cycling, stressed-out and nervous: cellular functions of c-Abl.Van Etten RA.Trends Cell Biol. 1999 May;9(5):179-86.
      • Applications
      • Western Blot (Cell lysate)
      • Western Blot (Cell lysate)
      • Western blot analysis of K-562 cells treated with pervanadate (1 mM) for 30 minutes (lanes 1 & 3). Some lanes were treated with alkaline phosphatase to remove phosphorylation on ABL1 (lanes 2 & 4), then the blots were probed with anti ABL1 (lanes 1 & 2), ABL1 (phospho Y245) polyclonal antibody (Cat # PAB7918) (lanes 3 & 4).
      • Enzyme-linked Immunoabsorbent Assay
      • Application Image
      • Western Blot (Cell lysate)
      • Western Blot (Cell lysate)
      • enlarge
      • Enzyme-linked Immunoabsorbent Assay
      • Gene Information
      • Entrez GeneID:
      • 25
      • Gene Name:
      • ABL1
      • Gene Alias:
      • ABL,JTK7,bcr/abl,c-ABL,p150,v-abl
      • Gene Description:
      • c-abl oncogene 1, receptor tyrosine kinase
      • Omim ID:
      • 189980
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
      • Other Designations:
      • Abelson murine leukemia viral (v-abl) oncogene homolog 1,OTTHUMP00000022375,OTTHUMP00000022376,bcr/c-abl oncogene protein,proto-oncogene tyrosine-protein kinase ABL1,v-abl Abelson murine leukemia viral oncogene homolog 1
      • Gene Pathway
      • Axon guidance
      • Cell cycle
      • Chronic myeloid leukemia
      • ErbB signaling pathway
      • Neurotrophin signaling pathway
      • Pathogenic Escherichia coli infection - EHEC
      • Pathways in cancer
      • Related Disease
      • Adenocarcinoma
      • Alzheimer Disease
      • Alzheimer disease
      • Breast cancer
      • Breast Neoplasms
      • Cardiovascular Diseases
      • Chronic Disease
      • Diabetes Complications
      • Esophageal Neoplasms
      • Genetic Predisposition to Disease
      • HIV Infections
      • Leukemia, chronic myeloid
      • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
      • Leukemia, Myeloid
      • Leukemia, Myeloid, Chronic
      • Metabolic Syndrome X
      • Neoplasms
      • Osteoporosis
      • Ovarian cancer
          • ... see more
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