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Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL
  • Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL

Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL

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貨號: MABT149
品牌: Millipore
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    • Description
      CatalogueNumberMABT149
      DescriptionAnti-CD11b/ITAMAntibody,cloneEP1345Y,rabbitmonoclonal
      AlternateNames
      • integrin,alphaM(complementcomponent3receptor3subunit)
      • CellsurfaceglycoproteinMAC-1subunitalpha
      • LeukocyteadhesionreceptorMO1
      • CR-3alphachain
      • CD11antigen-likefamilymemberB
      • integrin,alphaM(complementcomponentreceptor3,alpha
      • alsoknownasCD11b
        (p170),macrophageantigenalphapolypeptide)
      • macrophageantigenalphapolypeptide
      • neutrophiladherencereceptoralpha-Msubunit
      • integrinalpha-M
      • antigenCD11b(p170)
      • CD11bantigen
      • Neutrophiladherencereceptor
      BackgroundInformationIntegrinalpha-M(ITAM,ITGAM,CD11b,MAC-1alphasubunit,CR3alphachain)isthealphasubunitofITAM/beta-2complex(CD11b/CD18,Mac-1),aleukocyteadhesionheterodimericglycoprotein(1).ITAMbelongstointegrinalphachainfamilyanditispredominatelypresentedinhumanmyeloidcells,NK1cells,monocytes,andgranulocytes.ITAM/beta-2complexisareceptorforfibrinogen(bindingtoP1andP1peptidesofgammachain),factorX,andICAM1.ITAM/beta-2isimplicatedinadhesiveinteractionsofmonocytes,macrophages,andgranulocytes.Itisalsolinkedtomediationofcomplement-coatedparticleuptake(2).
      ProductInformation
      FormatDilutedCultureSupernatant
      Control
      • TF-1celllysate
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectCD11b/ITAMusingthisAnti-CD11b/ITAMAntibody,cloneEP1345Y,RabbitvalidatedforuseinWB,IC,IH(P),IP,FC.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      • FlowCytometry
      ApplicationNotesImmunohistochemistryAnalysis:1:100-1:250dilutionfromarepresentativelotdetectedCD11b/ITAMinhumanspleentissue.
      ImmunocytochemistryAnalysis:1:100-1:250dilutionfromarepresentativelotwasusedinIC.
      ImmunoprecipitationAnalysis:1:80dilutionfromarepresentativelotwasusedinIP.
      FlowCytometryAnalysis:1:20dilutionfromarepresentativelotwasusedinFC.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtohumanCD11b/ITAMattheC-terminus.
      EpitopeC-terminus
      CloneEP1345Y
      HostRabbit
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • CD11B
      • CR3A
      • MAC-1
      • MAC1A
      • SLEB6
      • CD11b
      • MO1A
      • MGC117044
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain.
      SUBUNITSTRUCTURE:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes.
      DOMAIN:TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage.
      INVOLVEMENTINDISEASE:GeneticvariationsinITGAMhasbeenassociatedwithsusceptibilitytosystemiclupuserythematosustype6(SLEB6)[MIM:609939].Systemiclupuserythematosus(SLE)isachronic,inflammatoryandoftenfebrilemultisystemicdisorderofconnectivetissue.Itaffectsprincipallytheskin,joints,kidneysandSEROsalmembranes.Itisthoughttorepresentafailureoftheregulatorymechanismsoftheautoimmunesystem.
      SEQUENCESIMILARITIES:Belongstotheintegrinalphachainfamily.
      Contains7FG-GAPrepeats.
      Contains1VWFAdomain.
      MolecularWeight~170kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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