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Millipore/MABT134 | Anti-VE-cadherin Antibody, clone BV6/MABT134/100 µL
  • Millipore/MABT134 | Anti-VE-cadherin Antibody, clone BV6/MABT134/100 µL

Millipore/MABT134 | Anti-VE-cadherin Antibody, clone BV6/MABT134/100 µL

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貨號: MABT134
品牌: Millipore
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    • Description
      CatalogueNumberMABT134
      ReplacesMAB1989
      DescriptionAnti-VE-cadherinAntibody,cloneBV6
      AlternateNames
      • Cadherin-5
      • 7B4Antigen
      BackgroundInformationHumanVascularEndothelial(VE)-cadherinisacalcium-dependentadhesionmoleculestrictlylocatedatcell-to-celljunctions.VE-cadherinispresentinalltypesofendothelium(veins,arteries,capillaryandlargevessels).Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells.Cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.VE-cadherinmayplayanimportantroleinendothelialcellBIOLOGythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.VE-cadherinalsoassociateswithalpha-cateninformingalinktotheCytoskeleton.
      ProductInformation
      FormatPurified
      Control
      • HUVECcelllysate
      PresentationPurifiedmousemonoclonalIgG2aκinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationThisAnti-VE-cadherinAntibody,cloneBV6isvalidatedforuseinWB,IC,FC,IH(P)forthedetectionofVE-cadherin.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • FlowCytometry
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedVE-cadherininthecell-celljunctionsofHUVECcells.

      ImmunohistochemistryAnalysis:A1:10-1:20dilutionofarepresentativelotwasusedbyanindependentlaboratoryinparaffin-embeddedtissuesections.Bufferedformalinfixationisrecommendedwithafixationperiodofnolongerthan12hours.Highheatantigenretrievalincitratebuffer(Cat.No.21545)isalsosuggested.Antibodycanalsobeusedtolabelacetone-fixedcryostatsectionsorcellsusingaimmunoperoxidasestainingprotocol(eg.IHCSelect?DetectionKit,Cat.No.DAB150)

      FlowCytometryAnalysis:ArepresentativelotwasusedinthepresenceofCa2+.Note:UsePBS+2-5mMEDTAforcelldetachment.

      WesternBlotAnalysis:Non-reducingconditionsmaybeneeded,Ca2+requiredinbuffer(2-5mM).
      BiologicalInformation
      ImmunogenHUVECcells
      CloneBV6
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      IsotypeIgG2aκ
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined.
      GeneSymbol
      • CDH5
      • CD144
      • 7B4
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton.ActsinconcertwithKRIT1toestablishandmaintaincorrectendothelialcellpolarityandvascularlumen.TheseeffectsaremediatedbyrecruitmentandactivationoftheParpolaritycomplexandRAP1B.RequiredforactivationofPRKCZandforthelocalizationofphosphorylatedPRKCZ,PARD3,TIAM1andRAP1Btothecelljunction.

      SUBUNITSTRUCTURE:Interactsviacadherin5domainwithPTPRB.InteractswithTRPC4.InteractswithKRIT1.

      SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:Foundatcell-cellboundariesandprobablyatcell-matrixboundaries.KRIT1andCDH5reciprocallyregulatetheirlocalizationtoendothelialcell-celljunctions.
      MolecularWeight~120kDaobserved.
      Thecalculatedmolecularweightis82kDabutitwillrunbetween~90-140kDabecausethisproteinisglycosolated.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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