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Millipore/MABE15 | Anti-Histone H2B Antibody, clone EP957Y, rabbit monoclonal/MABE15/100 µL
  • Millipore/MABE15 | Anti-Histone H2B Antibody, clone EP957Y, rabbit monoclonal/MABE15/100 µL

Millipore/MABE15 | Anti-Histone H2B Antibody, clone EP957Y, rabbit monoclonal/MABE15/100 µL

價格: ￥3204.00 市場價: 5340.00
貨號: MABE15
品牌: Millipore
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    • Description
      CatalogueNumberMABE15
      DescriptionAnti-HistoneH2BAntibody,cloneEP957Y,rabbitmonoclonal
      AlternateNames
      • histonecluster2,H2be
      • histone2,H2be
      • H2Bhistonefamily,memberQ
      • HistoneH2B.q
      • HistoneH2B-GL105
      • histoneH2Btype2-E
      BackgroundInformationChangesinchromatinstructureplayalargeroleintheregulationoftranscriptionineukaryotes(1).Thenucleosomeistheprimarybuildingblockofchromatin,andismadeupoffourcorehistoneproteins(H2A,H2B,H3andH4)(2).Acetylationofcorehistonesregulatesgeneexpression(2).HistoneH2Bisprimarilyacetylatedatlysines5,12,15,and20(3).UbiquitylationofHistoneH2Batlysine123byRad6hasbeenimplicatedintranscriptionalactivationandlysinemethylationonhistoneH3(4).HistoneH2BphosphorylationatSer10(foryeast)andSer14(formammaliancells)hasbeenlinkedtoregulationofapoptosisandmeiosis(5).
      ProductInformation
      FormatUnpurified
      Control
      • A431celllysate
      PresentationRabbitmonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      • Immunocytochemistry
      • Immunoprecipitation
      ApplicationNotesImmunohistochemistryAnalysis:A1:250–1:500dilutionfromapreviouslotdetectedHistoneH2Binhumanbreastcarcinoma.
      ImmunoprecipitationAnalysis:A1:30dilutionfromapreviouslotdetectedHistoneH2BinIP.
      ImmunocytochemistryAnalysis:A1:50–1:100dilutionfromapreviouslotdetectedHistoneH2BinHeLacells.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtohumanHistoneH2B.
      CloneEP957Y
      HostRabbit
      SpecificityThisantibodyrecognizesHistoneH2B.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteProventoreactwithhuman,mouse,andrat.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • H2B.1
      • H2B/q
      • H2BFQ
      • H2B
      • MGC119804
      • MGC129733
      • H2BGL105
      • GL105
      • H2BQ
      • MGC129734
      • MGC119802
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      Hasbroadantibacterialactivity.Maycontributetotheformationofthefunctionalantimicrobialbarrierofthecolonicepithelium,andtothebactericidalactivityofamnioticfluid.
      SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.Chromosome.
      PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.
      PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination.
      SEQUENCESIMILARITIES:BelongstothehistoneH2Bfamily.
      MolecularWeight~14kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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