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Millipore/MAB5386X | Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor? 488/MAB5386X/50 µg
  • Millipore/MAB5386X | Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor? 488/MAB5386X/50 µg

Millipore/MAB5386X | Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor? 488/MAB5386X/50 µg

價格: ¥4680.00 市場價: 7800.00

貨號: MAB5386X
品牌: Millipore
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    • Description
      CatalogueNumberMAB5386X
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NerveGrowthFactorReceptorAntibody,p75,AlexaFluor?488
      BackgroundInformationThelowaffinityNGFR(Nervegrowthfactorreceptor)isa75kDamembrane-spanningglycoproteinlackingintrinsictyrosinekinaseactivity.p75NGFRinteractswithTrkA,thehighaffinityNGFreceptorandpotentiatesTrkAsignalingatlowNGFconcentrations.Thep75receptorbindsnervegrowthfactor,brain-derivedneurotrophicfactor,neurotrophin-3andneurotrophin-4withvaryingspecificities.Thep75NGFRplaysanimportantroleinneurotrophicfactorsignalingandhasbeenshowntomodulatethesusceptibilityofselectivecellularpopulationstoprogrammedcelldeath.ItisexpressedonmanyneuronalcellstypesincludingmanyembryonicformsandthereceptorcanbeusedtoisolateneuronalProgenitorcells
      ProductInformation
      FormatAlexaFluor?488
      PresentationLiquid.Containsnopreservative.
      StorageandShippingInformation
      StorageConditionsAliquotandstoreat-20oC,orglycerol(ASCgradeorbetter)canbeadded(1:1)andtheantibodystoredat-20oCforupto12monthsfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationThisAnti-NerveGrowthFactorReceptorAntibody,p75,AlexaFluor488isvalidatedforuseinFC,ICforthedetectionofNerveGrowthFactorReceptor.
      KeyApplications
      • FlowCytometry
      • Immunocytochemistry
      ApplicationNotesOptimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenHumanmelanomacellline.
      CloneME20.4
      HostMouse
      SpecificityReactswiththelowaffinitynervegrowthfactorreceptor(NGFRp75).Theepitoperecognizedbytheantibodymapswithinthethirdorfourthcysteine-richrepeatsoftheNGFRmolecule.Reactivityhasnotbeenobservedwithrat,chicken,ormouseNGFR.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      • Pig
      • Rabbit
      • Sheep
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryNervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain.
      GeneSymbol
      • NGFR
      • p75(NTR)
      • TNFRSF16
      • Gp80-LNGFR
      • CD271
      Non-ReactiveSpecies
      • Chicken
      • Mouse
      • Rat
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.
      SIZE:427aminoacids;45183Da
      SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      DOMAIN:SwissProt:P08138DeathdomainisresponsIBLeforinteractionwithRANBP9.
      PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues.
      SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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