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Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL
  • Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL

Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL

價(jià)格: ￥5424.00 市場(chǎng)價(jià): 9040.00
貨號(hào): MAB382
品牌: Millipore
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    • Description
      CatalogueNumberMAB382
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-MyelinBasicProteinAntibody,a.a.129-138,clone1
      AlternateNames
      • MyelinA1protein
      • Myelinmembraneencephalitogenicprotein
      • myelinbasicprotein
      BackgroundInformationTheclassicgroupofMBPisoforms(isoforms4-14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.TheyhavearoleinbothitsformationandstABIlization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoforms1-3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalposttranslationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.

      MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.

      Isoform1Golli-MBP1,HOG7,33kDa

      Isoform2Golli-MBP2,HOG5,21.5kDa

      Isoform3MBP1,21.5kDa

      Isoform4MBP2,20.2kDa

      Isoform5MBP3,18.5kDa

      Isoform6MBP4,17.2kDa

      (SP_P02686)
      ProductInformation
      FormatCultureSupernatant
      Control
      • Braintissue
      PresentationCulturesupernatantcontaining0.2MTris/HCl,pH7.4with5-10%fetalcalfserumand0.1%sodiumazide
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCinundilutedaliquotsfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationThisAnti-MyelinBasicProteinAntibody,a.a.129-138,clone1isvalidatedforuseinELISA,IH,IH(P),RIA,WBforthedetectionofMyelinBasicProtein.
      KeyApplications
      • ELISA
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • RADIoimmunoassay
      • WesternBlotting
      ApplicationNotesImmunohistochemistry(paraffin)Analysis:
      OptimalStainingWithCitrateBuffer,pH6.0,EpitopeRetrieval:RatCerebellum
      Immunohistologyonfrozensectionsat1:10

      WesternBlotAnalysis:
      ApreviouslotofthisantibodywasusedinWesternBlot.

      ELISA:
      A1:200-1:1,000dilutionofapreviouslotwasusedinELISA.

      RIA:
      ApreviouslotofthisantibodywasusedinRadioimmunoassay.

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenBovinemyelinbasicprotein
      Epitopea.a.129-138
      Clone1
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityReactswithMBPfromhuman,bovineandrat,epitope129-138
      IsotypeIgG2a
      SpeciesReactivity
      • Bovine
      • Human
      • Rat
      SpeciesReactivityNoteReactsweaklywithrabbit.Doesnotreactwithguineapig.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes.
      GeneSymbol
      • MBP
      • MGC99675
      • Golli-mbp
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P02686#TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.Theyhavearoleinbothitsformationandstabilization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.
      SIZE:304aminoacids;33117Da
      SUBUNIT:Homodimer;isoform3existsasahomodimer.
      SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.
      TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.
      PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.
      DISEASE:SwissProt:P02686#Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).
      SIMILARITY:SwissProt:P02686##Belongstothemyelinbasicproteinfamily.
      MolecularWeight19kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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