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Millipore/MAB3790 | Anti-β-Catenin Antibody, clone 9F12.2/MAB3790/200 µg
  • Millipore/MAB3790 | Anti-β-Catenin Antibody, clone 9F12.2/MAB3790/200 µg

Millipore/MAB3790 | Anti-β-Catenin Antibody, clone 9F12.2/MAB3790/200 µg

價格: ￥3576.00 市場價: 5960.00
貨號: MAB3790
品牌: Millipore
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    • Description
      CatalogueNumberMAB3790
      Replaces04-1002
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-β-CateninAntibody,clone9F12.2
      BackgroundInformationBeta-catenin,thevertebratehomologueofDrosophilasegmentpolaritygenearmADIllo,andkeyelementoftheWntsignaltransductionpathways,isimportantinembryogenesis,celltransformation,andintercellularadhesionincludingtheadhesion,motilityandmetastasisofcancercells.Thus,cateninproteinexpression,regulationandlocalizationarepotentiallyimportantMarkerstopredictmotilityandinvasivenessofepithelialneoplasms.Besidesadhesionfunctions,beta-cateninbindstothetumorsuppressorgeneAPC.APCmutationdisturbstheequilibriumandcytoplasmiclevelsoffreebeta-cateninlevelinthecellandmayhavearoleintumOrigenesis.
      ProductInformation
      FormatPurified
      Control
      • Westernblotpositivecontrol:A431cellline
      PresentationProteinApurifiedimmunoglobulin.Liquidin0.02MPhosphateBuffer,0.25MNaCl,with0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsMaintainat2-8°Cforupto12monthsfromdateofreceipt.
      Applications
      ApplicationDetectβ-CateninalsoknownasbetacateninwithAnti-β-CateninAntibody,clone9F12.2(MouseMonoclonalAntibody),thathasbeendemonstratedtoworkinWB.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternblot:2-5μg/mL

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoresidues27-37ofHumanbetacatenin.Sequenceis100%identicalinmouse,rat,Xenopus,zebrafish,chicken,porcine,andgerbil.
      Clone9F12.2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizeshumanbetacatenin.Thisantibodydetectsabandofapproximately97kDainWesternblotanalysisofA431celllysate.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryBeta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactinCytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM]
      GeneSymbol
      • CTNNB1
      • FLJ25606
      • CTNNB
      • Beta-catenin
      • PRO2286
      • FLJ37923
      • DKFZp686D02253
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P35222#InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.
      SIZE:781aminoacids;85497Da
      SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2.InteractswithSLC30A9(Bysimilarity).
      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2promotesnucleartranslocation.
      TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.
      PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33.&EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding.&UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1X(Probable).Itsubiquitinationleadstoitssubsequentproteasomaldegradation.
      DISEASE:"SwissProt:P35222#ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife.&DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor.&DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren.&AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1."
      SIMILARITY:SwissProt:P35222##Belongstothebeta-cateninfamily.&Contains12ARMrepeats.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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