Immunogen | Syntheticpeptidecorrespondingtoaminoacids439-458ofthecytoplasmictailofhumanCD4. |
Epitope | intracellular |
Clone | 024-10D6.B3 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | RecognizesthecytoplasmictailofCD4.Manyfunctionshavebeenassignedtothistail,includinganti-viralregulation(down/upregulationofCD4),T-cellmaturation,activationanddifferentiation,andLcksignaltransduction,amongothers.ThisantibodyisusefulasacontrolforstudiesinvolvingtargetingofintracellularproteindomainsofTcells. |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P01730#AccessoryproteinforMHCclass-IIantigen/T-cellreceptorinteraction.MayregulateT-cellactivation.Inducestheaggregationoflipidrafts. SIZE:458aminoacids;51111Da SUBUNIT:AssociateswithLCK.BindstoHIV-1gp120andtoP4HB/PDIanduponHIV-1bindingtothecellmembrane,ispartofP4HB/PDI-CD4-CXCR4-gp120complex.InteractswithHIV-1Envelopepolyproteingp160andproteinVpu. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note=Localizestolipidrafts.RemovedfromplasmamembranebyHIV-1Nefproteinthatincreasesclathrin-dependentendocytosisofthisantigentotargetittolysosomaldegradation.Cellsurfaceexpressionisalsodown-modulatedbyHIV-1Envelopepolyproteingp160thatinteractswith,andsequestersCD4intheendoplasmicreticulum. PTM:PalmitoylationandassociationwithLCKcontributetotheenrichmentofCD4inlipidrafts. SIMILARITY:SwissProt:P01730##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain. MISCELLANEOUS:PrimaryreceptorforHIV-1. |