BackgroundInformation | Oligodendrocytesandastrocytesarederivedfromcommonprecursorcells,glioblasts(Sommer,1981).O-Antigensaresulfatides,whichfunctionasdifferentiationMarkersonthesurfaceofoligodendrocytesofthecentralnervoussystem.O4isformedpostnatally(Schachner,1981)andisamarkerforcellbodiesandprocessesofoligodendrocytestypesIandII(hairyeyeballtype).Duringoligodendrocytedifferentiation,O4occursinpro-oligodendrocytes,butnotinO-2A-Progenitorcells.O4occursfromday3onwardsincellculturesofembryonicmousebrain.Anti-O4canbeusedinmyelination,demyelinationandremyelinationstudiesandinregenerationexperiments. |