Immunogen | Neuron-specificenolasefromhumanbrain. |
Clone | 5E2 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Humangammaneuronspecificenolase.Recognizesa45kDbandcorrespondingtogammaNSEonimmunoblotsofhumanbrainextracts. |
Isotype | IgG2a |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesoneofthethreeenolaseisoenzymesfoundinmammals.Thisisoenzyme,ahomodimer,isfoundinmatureneuronsandcellsofneuronalorigin.Aswitchfromalphaenolasetogammaenolaseoccursinneuraltissueduringdevelopmentinratsandprimates. |
GeneSymbol | - ENO2
- NSE
- Gamma-enolase
- EC4.2.1.11
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P09104#Hasneurotrophicandneuroprotectivepropertiesonabroadspectrumofcentralnervoussystem(CNS)neurons.Binds,inacalcium-dependentmanner,toculturedneocorticalneuronsandpromotescellsurvival(Bysimilarity). COFACTOR:Magnesium.RequiredforcatalysisandforstABIlizingthedimer. SIZE:434aminoacids;47269Da SUBUNIT:Mammalianenolaseiscomposedof3isozymesubunits,alpha,betaandgamma,whichcanformhomodimersorheterodimerswhicharecell-typeanddevelopment-specific. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellmembrane(Bysimilarity).Note=Cantranslocatetotheplasmamembraneineitherthehomodimeric(alpha/alpha)orheterodimeric(alpha/gamma)form(Bysimilarity). TISSUESPECIFICITY:Thealpha/alphahomodimerisexpressedinembryoandinmostadulttissues.Thealpha/betaheterodimerandthebeta/betahomodimerarefoundinstriatedmuscle,andthealpha/gammaheterodimerandthegamma/gammahomodimerinneurons.DEVELOPMENTALSTAGE:Duringontogenesis,thereisatransitionfromthealpha/alphahomodimertothealpha/betaheterodimerinstriatedmusclecells,andtothealpha/gammaheterodimerinnervecells. SIMILARITY:SwissProt:P09104##Belongstotheenolasefamily. |