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Millipore/MAB2059 | Anti-Integrin β4 Antibody, clone ASC-8/MAB2059/100 µg
  • Millipore/MAB2059 | Anti-Integrin β4 Antibody, clone ASC-8/MAB2059/100 µg

Millipore/MAB2059 | Anti-Integrin β4 Antibody, clone ASC-8/MAB2059/100 µg

價(jià)格: ￥4440.00 市場(chǎng)價(jià): 7400.00
貨號(hào): MAB2059
品牌: Millipore
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    • Description
      CatalogueNumberMAB2059
      Replaces05-283
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Integrinβ4Antibody,cloneASC-8
      AlternateNames
      • CD104
      • MAB2059Z
      ProductInformation
      FormatPurified
      PresentationLiquidin0.02MPBpH7.6,0.25MNaClcontaining0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto6months.
      Applications
      ApplicationAnti-Integrinβ4Antibody,cloneASC-8isanantibodyagainstIntegrinβ4foruseinFC,IP,IH.
      KeyApplications
      • FlowCytometry
      • Immunoprecipitation
      • Immunohistochemistry
      • AffectsFunction
      ApplicationNotesImmunoprecipitation:ArepresentativelotofthisantibodycloneprecipitatedPAGEbandsof66,76,120,135and200kDa(reduced)or66,110,125,130and190kDa(non-reduced)fromsurface-biotinylatedSCC9cells.

      Immunohistochemistry:Arepresentativelotofthisantibodyclonewasusedinimmunohistochemistry(acetone-fixedfrozenhumanepithelialtissuesincludingtongue,foreskinandovary.Notforuseonformalin-fixedtissue).

      FlowCytometry:Arepresentativelotofthisantibodyclonestainedhumansquamouscellcarcinoma(SCC9),ovariancarcinoma(SKOV-3)andumbilicalveinendothelium(HUVEC).StainsRKOorK562cellstransfectedforCD104expression.Doesnotstainmonocytes,neutrophils,lymphocytes,Tcells,Bcellsorplatelets.

      FunctionalActivityAssay:Arepresentativelotofthisantibodycloneinducedasub-basalsplitatthebasementmembraneinnon-woundedtissue.Inaddition,woundclosurewassignificantlyinhibitedbyASC-8,astheepithelialtongueonlycovered40percentofthewoundareaat120hourspost-wounding.Theseresultsdemonstratethattheβ4adhesion-blockingantibodymayhaveadverseeffectsonnormaltissue(Egles,C.,etal.,2010).

      Workingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenHumansquamouscellcarcinomacells(SCC9)
      CloneASC-8
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityHumanbeta4integrin(CD104)
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryIntegrinsareheterodimerscomprisedofalphaandbetasubunits,thatarenoncovalentlyassociatedtransmembraneglycoproteinreceptors.Differentcombinationsofalphaandbetapolypeptidesformcomplexesthatvaryintheirligand-bindingspecificities.Integrinsmediatecell-matrixorcell-celladhesion,andtransducedsignalsthatregulategeneexpressionandcellgrowth.Thisgeneencodestheintegrinbeta4subunit,areceptorforthelaminins.Thissubunittendstoassociatewithalpha6subunitandislikelytoplayapivotalroleinthebiologyofinvasivecarcinoma.Mutationsinthisgeneareassociatedwithepidermolysisbullosawithpyloricatresia.Multiplealternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene.
      GeneSymbol
      • ITGB4
      • CD104
      • GP150
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P16144#Integrinalpha-6/beta-4isareceptorforlaminin.Itplaysacriticalstructuralroleinthehemidesmosomeofepithelialcells.
      SIZE:1822aminoacids;202151Da
      SUBUNIT:Heterodimerofanalphaandabetasubunit.Beta-4associateswithalpha-6.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:Integrinalpha-6/beta-4ispredominantlyexpressedbyepithelia.Isoformbeta-4Disalsoexpressedincolonandplacenta.Isoformbeta-4Eisalsoexpressedinepidermis,lung,duodenum,heart,spleenandstomach.
      DOMAIN:SwissProt:P16144Thefibronectintype-III-likedomainsbindBPAG1andplectinandprobablyalsorecruitBP230.
      DISEASE:SwissProt:P16144#DefectsinITGB4areacauseofepidermolysisbullosaletaliswithpyloricatresia(EB-PA)[MIM:226730];alsoknownasjunctionalepidermolysisbullosawithpyloricatresia(PA-JEB)oraplasiacutiscongenitawithgastrointestinalatresia.EB-PAischaracterizedbymucocutaneousfragilityandgastrointestinalatresia,whichmostcommonlyaffectsthepylorus.&DefectsinITGB4areacauseofgeneralizedatrophicbenignepidermolysisbullosa(GABEB)[MIM:226650].Thisnonlethalformofjunctionalepidermolysisbullosaischaracterizedbylife-longblisteringoftheskin,associatedwithhairandtoothabnormalities.
      SIMILARITY:Belongstotheintegrinbetachainfamily.&Contains1Calx-betadomain.&Contains4fibronectintype-IIIdomains.&Contains1VWFAdomain.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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