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Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg
  • Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg

Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg

價格: ￥4068.00 市場價: 6780.00
貨號: MAB2029
品牌: Millipore
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    • Description
      CatalogueNumberMAB2029
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-ChondroitinSulfateProteoglycanAntibody,clone9.2.27
      ProductInformation
      FormatPurified
      PresentationPurifiedfromascitesbyProteinASepharose?chromatography.Purifiedimmunoglobulinin0.02MPBSpH7.6,0.25MNaClcontaining0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsMaintainbetween2and8°Cinundilutedaliquotsforupto6months.
      Applications
      ApplicationDetectChondroitinSulfateProteoglycanusingthisAnti-ChondroitinSulfateProteoglycanAntibody,clone9.2.27validatedforuseinFC,IF&IP.
      KeyApplications
      • FlowCytometry
      • Immunofluorescence
      • Immunoprecipitation
      ApplicationNotesImmunofluorescencemicroscopyofcellsinculture(Bumoietal.,1984;Schrappeetal.,1992).Also,LeggJetal(2003)Development130:6049-6063{3%PFAfixedfrozensections}.

      Immunoelectronmicroscopy(Bumoietal.,1984)

      Immunoprecipitation:1μg/10E6cells(Bumoietal.,1984;Morganetal.,1981)

      FACSanalysis:1-2μg/10E6cells

      FunctionalblockofmelanomacellspreADIng(Morganetal.,1981),gliomacellproliferation3andtumorgrowthinnudemice(Morganetal.,1981;Schrappeetal.,1992).

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenHumanM14melanomacellextractdepletedoffibronectinandboundbylensculinarislectin-Sepharose?(Morganetal.,1981).
      Clone9.2.27
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizesmaturechondroitinsulfateproteoglycancoreglycoproteinof250kDaaswellasprecursorpolypeptidesof210,220and240kDa(Bumoietal.,1984).Reactswithhumanmelanoma,gliomaandproliferatingbrainendothelialcells.
      IsotypeIgG2a
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreadingonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
      GeneSymbol
      • CSPG4
      • MSK16
      • MCSP
      • NG2
      • MCSPG
      • MEL-CSPG
      • HMW-MAA
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.


      SIZE:2322aminoacids;250497Da

      SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.

      SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).

      TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.



      PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).


      SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.

      MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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