Rabbit monoclonal antibody raised against synthetic peptide of human CASP3.
Immunogen:
A synthetic peptide corresponding to human CASP3.
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
Form:
Liquid
Purification:
Affinity purification
Isotype:
IgG
Recommend Usage:
Immunohistochemistry (1:50-1:200)Immunoprecipitation (1:50)Western Blot (1:500-1:2000)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction:
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Applications
Western Blot (Cell lysate)
Western blot analysis of (1) Jurkat cell lysate; (2) COLO cells lysate with CASP3 monoclonal antibody.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer"s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
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