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Millipore/MAB1598 | Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8/MAB1598/100 µg
  • Millipore/MAB1598 | Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8/MAB1598/100 µg

Millipore/MAB1598 | Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8/MAB1598/100 µg

價(jià)格: ￥4308.00 市場價(jià): 7180.00
貨號: MAB1598
品牌: Millipore
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    • Description
      CatalogueNumberMAB1598
      Replaces04-1066
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-PostSynapticDensityProtein95Antibody,clone7E3-1B8
      AlternateNames
      • PSD-95
      BackgroundInformationThepostsynapticdensity(PSD)isanelectrondensestructurejustbeneaththepostsynapticmembrane.SeveralfunctionshavebeenproposedforthePSDincludingregulatingreceptornumberandclustering,anchoringsignaltransductionmoleculesatthesynapseandmediatingadhesionbetweenthepresynapticandpostsynapticmembranes.ThemostabundantPSDproteinisthe[alpha]subunitofthetypeIIcalcium/calmodulindependentproteinkinase([alpha]CaMKII).Thisproteinislikelytoplayaroleinthecalcium-mediatedsignaltransductionatthesynapsethatmediatescertainformsofsynapticplasticity.AnothermajorPSDproteinisPSD-95,amemberoftheguanylatekinasefamily(GUK)ofproteins.
      ProductInformation
      FormatPurified
      Control
      • Mousebrain,ratbraintissue
      PresentationPurifiedmoustmonoclonalIgG2aliquidinbuffercontainingPBS,pH7.2,with0.09%sodiumazideand50%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationAnti-PostSynapticDensityProtein95Antibody,clone7E3-1B8isanantibodyagainstPostSynapticDensityProtein95foruseinIC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunocytochemistry:
      ApreviouslotofthisantibodywasusedinIC.

      Immunoprecipitation:
      ApreviouslotofthisantibodywasusedinIP.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenRecombinantratPSD-95
      Clone7E3-1B8
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityReactswithrecombinantratPSD-95andidentifiesabandatapproximately~100kDa,correspondingtoPSD-95,onwesternblotsofratbrain,mousebrainandbovinebrainextracts.Alsopresentinratbrainandmousebraintissueextractsarebandsofapproximately80kDaand50kDa.PSD-95isbelievedtoinitiateNMDAreceptorclusteringonthepostsynapticmembrane.
      IsotypeIgG2a
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Bovine
      SpeciesReactivityNoteExpectedtoreactwithhumanbasedonsequencehomology
      AntibodyTypeMonoclonalAntibody
      EntrezGeneSummaryThisgeneencodesamemberofthemembrane-associatedguanylatekinase(MAGUK)family.ItheteromultimerizeswithDLG2.WithDLG2itisrecruitedintothesameNMDAreceptorandpotassiumchannelclusters.ThesetwoMAGUKproteinsmayinteractatpostsynapticsitestoformamultimericscaffoldfortheclusteringofreceptors,ionchannels,andassociatedsignalingproteins.
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P78352#InteractswiththecytoplasmictailofNMDAreceptorsubunitsandshaker-typepotassiumchannels.RequiredforsynapticplasticityassociatedwithNMDAreceptorsignaling.OverexpressionordepletionofDLG4changestheratioofexcitatorytoinhibitorysynapsesinhippocampalneurons.MayreducetheamplitudeofACCN3acid-evokedcurrentsbyretainingthechannelintracellularly.MayregulatetheintracellulartraffickingofADR1B(Bysimilarity).
      SIZE:724aminoacids;80495Da
      SUBUNIT:InteractsthroughitsfirsttwoPDZdomainswithGRIN2A,GRIN2B,GRIN2C,GRIN2D,ACCN3,certainspliceformsofGRIN1,KCND2,CXADRandSYNGAP1.InteractsthroughitssecondPDZdomainwiththePDZdomainofNOS1ortheC-terminusofCAPON.MayinteractwithHTR2A.Interactsthroughitsguanylatekinase-likedomainwithDLGAP1/GKAP,DLGAP2,DLGAP3,DLGAP4,MAP1A,andBEGAIN(Bysimilarity).InteractsthroughitsfirsttwoPDZdomainswithKCNA1,KCNA2,KCNA3,KCNA4andERBB4.InteractsthroughitsfirstPDZdomainwithGRIK2,KCNA4andCRIPT.InteractsthroughitsthirdPDZdomainwithNLGN1,andprobablywithNLGN2andNLGN3.Interactsthroughitsguanylatekinase-likedomainwithKIF13B.Isoform2interactsthroughanL27domainwithHGS/HRSandthefirstL27domainofCASK.
      SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein.Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity.Celljunction,synapse.Note=Highlevelsinpostsynapticdensityofneuronsintheforebrain.AlsoinpresynapticregionofinhibitorysynapsesformedbycerebellarbasketcellsonaxonhillocksofPurkinjecells.
      TISSUESPECIFICITY:Brain.
      DOMAIN:SwissProt:P78352ThePDZdomain3mediatesinteractionwithADR1B.&TheL27domainneartheN-terminusofisoform2isrequiredforHGS/HRS-dependenttargetingtopost-synapticdensity.
      PTM:Palmitoylationofisoform1isrequiredfortargetingtopostsynapticdensity(Bysimilarity).
      SIMILARITY:BelongstotheMAGUKfamily.&Contains1guanylatekinase-likedomain.&Contains3PDZ(DHR)domains.&Contains1SH3domain.
      MolecularWeight~95kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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