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Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
  • Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg

Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg

價(jià)格: ¥3948.00 市場(chǎng)價(jià): 6580.00

貨號(hào): MAB1149
品牌: Millipore
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    • Description
      CatalogueNumberMAB1149
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Tie-2Antibody,extracellular,clone4G8HE
      OverviewPurity:Greaterthan95%bySDS-PAGE.0.22micronsterilefiltered.
      AlternateNames
      • Angiopoietin-1Receptor
      • p140TEK
      BackgroundInformationTie-2isanendothelial-specificreceptortyrosinekinaseandareceptorforangiopoietin1.ItisatypeImembraneproteinthatisexpressedpredominantlyintheendotheliumofactivelygrowingbloodvesselsandmayrepresenttheearliestmammalianendothelialcelllineageMarker.Tie-2islikelyinvolvedintheregulationofendothelialcellproliferationanddifferentiationandmaydirectthespecialorientationofendothelialcellsduringtheformationofbloodvessels.
      ProductInformation
      FormatPurified
      Control
      • POSITIVECONTROL:placentaandlungtissue.
      PresentationImmunoglobulinpurifiedbyproteinGaffinitychromatography.LiquidinPBS,pH7.4,containing0.05%Bronidoxasapreservative.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months.
      Applications
      ApplicationAnti-Tie-2Antibody,extracellular,clone4G8HEdetectslevelofTie-2&hasbeenpublished&validatedforuseinELISA,FC&WB.
      KeyApplications
      • ELISA
      • FlowCytometry
      • WesternBlotting
      ApplicationNotesWesternblot:10μg/mL.Recognizesabandmigratingatapproximately140kDacorrespondingtomouseTie-2.

      FACS:10μg/mL

      ELISA

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenTheextracellulardomainofmouseTie-2receptor.
      Epitopeextracellular
      Clone4G8HE
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRat
      SpecificityRecognizesmouseTie-2Receptor.
      IsotypeIgG1
      SpeciesReactivity
      • Mouse
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase.
      GeneSymbol
      • TEK
      • CD202B
      • TIE2
      • VMCM1
      • VMCM
      • hTIE2
      • CD202b
      • TIE-2
      • EC2.7.10.1
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation.
      SIZE:1124aminoacids;125811Da
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney.
      DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels.
      SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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