TP53 (phospho S46) (Human) ELISA Kit is designed to detect and quantify the level of human p53 protein that is phosphorylated at serine residue 46. Since the amino acid sequence surrounding serine 46 is not conserved in mouse and rat p53, this ELISA kit can not be used for mouse and rat cells. This assay is intended for the detection of phosphorylated human p53 at serine 46 from cell lysate.
Calibration Range:
1.56 to 100 U/mL
Limit of Detection:
1.450 U/mL
Reactivity:
Human
Quality Control Testing:
Standard curveThe standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction:
Store the kit at 4°C.
Protocol:
Please click to inquiry
Suitable Sample:
Cell Lysate
Sample Volume:
100 uL
Label:
HRP-conjugate
Detection Method:
Colorimetric
Regulation Status:
For research use only (RUO)
Datasheet:
Download
Publication Reference
1.
High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.Pauloin T, Dutot M, Joly F, Warnet JM, Rat P.Mol Vis. 2009;15:577-83. Epub 2009 Mar 23.
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it"s believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
Other Designations:
p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53
Interactome
Gene Pathway
Amyotrophic lateral sclerosis (ALS)
Apoptosis
Basal cell carcinoma
Bladder cancer
Cell cycle
Chronic myeloid leukemia
Colorectal cancer
Endometrial cancer
Glioma
Huntington"s disease
MAPK signaling pathway
Melanoma
Neurotrophin signaling pathway
Non-small cell lung cancer
p53 signaling pathway
Pancreatic cancer
Pathways in cancer
Prostate cancer
Small cell lung cancer
Thyroid cancer
Wnt signaling pathway
Related Disease
Abortion, Habitual
Abortion, Spontaneous
Acquired Hyperostosis Syndrome
Acute Disease
Adenocarcinoma
Adenocarcinoma, Clear Cell
Adenocarcinoma, Follicular
Adenocarcinoma, Mucinous
Adenoma
Adenoma, Liver Cell
Adenomatous Polyposis Coli
Adrenal Cortex Neoplasms
Albuminuria
Alcoholism
Alzheimer Disease
Alzheimer disease
Ameloblastoma
Aneuploidy
Anoxia
... see more
Anus Neoplasms
Arsenic Poisoning
Arthritis, Psoriatic
Arthritis, Rheumatoid
Astrocytoma
Ataxia telangiectasia
Atherosclerosis
Autoimmune Diseases
Azoospermia
Balkan Nephropathy
Barrett Esophagus
Bipolar Disorder
Bone Neoplasms
Brain Infarction
Brain Injuries
Brain Ischemia
Brain Neoplasms
Breast cancer
Breast Neoplasms
Carcinoma
Carcinoma in Situ
Carcinoma, Adenosquamous
Carcinoma, Basal Cell
Carcinoma, Ductal
Carcinoma, Ductal, Breast
Carcinoma, Endometrioid
Carcinoma, Hepatocellular
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Large Cell
Carcinoma, Lobular
Carcinoma, Non-Small-Cell Lung
Carcinoma, Pancreatic Ductal
Carcinoma, Papillary
Carcinoma, Renal Cell
Carcinoma, Squamous Cell
Carcinoma, Transitional Cell
Cardiovascular Diseases
Carotid Artery Diseases
Carotid Artery Thrombosis
Cell Transformation, Neoplastic
Cerebellar Neoplasms
Cerebral Infarction
Cervical Intraepithelial Neoplasia
Chagas Disease
Cholecystitis
Choriocarcinoma
Choroid Plexus Neoplasms
Chromosomal Instability
Chromosome Aberrations
Chromosome Deletion
Chronic Disease
Cicatrix, Hypertrophic
Cocarcinogenesis
Cognition Disorders
Colitis, Ulcerative
Colon cancer
Colonic Neoplasms
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
Condylomata Acuminata
Conjunctival Neoplasms
Constriction, Pathologic
Coronary Artery Disease
Coronary Disease
Coronary Restenosis
Craniocerebral Trauma
Crohn Disease
Crohn"s disease
Cystadenocarcinoma, Serous
Delayed Graft Function
Depressive Disorder, Major
Diabetes Mellitus
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Digestive System Neoplasms
Disease Progression
Disease Susceptibility
DNA Damage
Down Syndrome
Duodenal Ulcer
Edema
Ehlers-Danlos Syndrome
Endometrial Hyperplasia
Endometrial Neoplasms
Endometriosis
Epidermodysplasia Verruciformis
Epstein-Barr Virus Infections
Esophageal Neoplasms
Fallopian Tube Neoplasms
Gallbladder Neoplasms
Ganglioglioma
Gastritis
Gastritis, Atrophic
Gastroesophageal Reflux
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Genital Neoplasms, Female
Genomic Instability
Glaucoma
Glaucoma, Open-Angle
Glioblastoma
Glioma
Graft Occlusion, Vascular
Graves Disease
Hashimoto Disease
Head and Neck Neoplasms
Helicobacter Infections
Hematologic Diseases
Hepatitis B
Hepatitis B, Chronic
Hepatitis C
Hepatitis C, Chronic
Herpes Simplex
HIV Infections
Hodgkin Disease
Hydatidiform Mole
Hypopharyngeal Neoplasms
Hypotension
Infertility, Female
Infertility, Male
Inflammation
Inflammatory Bowel Diseases
Intestinal Neoplasms
Intracranial Thrombosis
Keloid
Keratosis
Kidney Failure, Chronic
Kidney Neoplasms
Laryngeal Neoplasms
Leber hereditary optic neuropathy
Leiomyoma
Leukemia
Leukemia, B-Cell, Chronic
Leukemia, chronic myeloid
Leukemia, Lymphocytic, Chronic
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Leukemia, Myeloid, Chronic
Leukoplakia
Leukoplakia, Oral
Lichen Planus, Oral
Li-Fraumeni Syndrome
Lissencephaly
Liver Cirrhosis
Liver Neoplasms
Low Tension Glaucoma
Lung Neoplasms
Lupus Erythematosus, Systemic
Lupus Nephritis
Lymphatic Metastasis
Lymphoma
Lymphoma, B-Cell
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Follicular
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Large-Cell
Lymphoma, Mantle-Cell
Lymphoma, Non-Hodgkin
Lymphoproliferative Disorders
Malignant melanoma
Medulloblastoma
Melanoma
Meningeal Neoplasms
Meningioma
Mental Retardation
Metaplasia
Microsatellite Instability
Mouth Neoplasms
Multiple Myeloma
Multiple Sclerosis
Myelodysplastic Syndromes
Nasopharyngeal Neoplasms
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasms
Neoplasms, Basal Cell
Neoplasms, Glandular and Epithelial
Neoplasms, Hormone-Dependent
Neoplasms, Radiation-Induced
Neoplasms, Second Primary
Neoplasms, Squamous Cell
Nerve Sheath Neoplasms
Neural Tube Defects
Neurilemmoma
Neuroectodermal Tumors, Primitive
Neurofibroma
Neurofibromatosis
Neurofibromatosis 2
Neuroma, Acoustic
Neuropsychological Tests
Neutropenia
Nijmegen Breakage Syndrome
Nose Neoplasms
Obesity
Obesity
Occupational Diseases
Ocular Hypertension
Oligodendroglioma
Oligospermia
Optic Atrophy, Hereditary, Leber
Oral Submucous Fibrosis
Oropharyngeal Neoplasms
Osteoarthritis
Osteosarcoma
Ovarian cancer
Ovarian Neoplasms
Pancreatic cancer
Pancreatic Neoplasms
Papilloma, Choroid Plexus
Papillomavirus Infections
Pemphigus
Penile Neoplasms
Peptic Ulcer
Peritoneal Neoplasms
Pharyngeal Neoplasms
Postoperative Complications
Precancerous Conditions
Prostate cancer
Prostatic Hyperplasia
Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Psoriasis
Pterygium
Pulmonary Disease, Chronic Obstructive
Pulmonary Fibrosis
Radiation Injuries
Radiodermatitis
Rectal Neoplasms
Recurrence
Roseolovirus Infections
Sarcoma
Sarcoma, Kaposi
Schizophrenia
Schizophrenia
Skin Diseases
Skin Neoplasms
Small Cell Lung Carcinoma
Spinal Dysraphism
Stomach Neoplasms
Stomach Ulcer
Subarachnoid Hemorrhage
Substance-Related Disorders
Sunburn
The p53 tumor suppressor protein
Thyroid Diseases
Thyroid Neoplasms
Thyroiditis, Autoimmune
Tobacco Use Disorder
Tongue Neoplasms
Tumor Virus Infections
Uremia
Urinary Bladder Neoplasms
Urologic Diseases
Uterine Cervical Diseases
Uterine Cervical Dysplasia
Uterine Cervical Neoplasms
Uterine Neoplasms
Waldenstrom Macroglobulinemia
Wegener Granulomatosis
Werner syndrome
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