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Abnova/CCND2 Split FISH Probe/1kit/FS0036
  • Abnova/CCND2 Split FISH Probe/1kit/FS0036

Abnova/CCND2 Split FISH Probe/1kit/FS0036

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貨號: FS0036
品牌: Abnova
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  • 詳情
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  • 常見問題
      • Specification
      • Gene Info
      • Interactome
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
      • Form:
      • Liquid
      • Quality Control Testing:
      • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.QC Testing of FS0036
      • Supplied Product:
      • DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Note:
      • Hybridization position of the probes on the chromosome.
      • Probe 1:Size:Fluorophore:Location:
      • CCND2Approximately 580kbTexas Red12p13.32
      • Probe 2:Size:Fluorophore:Location:
      • CCND2Approximately 690kbFITC12p13.32
      • Probe Gap:
      • The gap between two probes is approximately 90 kb
      • Origin:
      • Human
      • Source:
      • Genomic DNA
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulation Status:
      • For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Publication Reference
      • 1.
      • Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B-cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall.Chuang WY, Chang H, Chang GJ, Wang TH, Chang YS, Wang TH, Yeh CJ, Ueng SH, Chien HP, Chang CY, Wan YL, Hsueh C.Histopathology. 2016 Dec 29. [Epub ahead of print]
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • Gene Information
      • Entrez GeneID:
      • 894
      • Gene Name:
      • CCND2
      • Gene Alias:
      • KIAK0002,MGC102758
      • Gene Description:
      • cyclin D2
      • Omim ID:
      • 123833
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq
      • Other Designations:
      • G1/S-specific cyclin D2
      • Interactome
      • Interactome
      • Gene Pathway
      • Cell cycle
      • Focal adhesion
      • Jak-STAT signaling pathway
      • p53 signaling pathway
      • Wnt signaling pathway
      • Related Disease
      • Breast cancer
      • Breast Neoplasms
      • Carcinoma, Hepatocellular
      • Diabetes Mellitus, Type 2
      • Genetic Predisposition to Disease
      • Hepatitis B
      • Kidney Failure, Chronic
      • Liver Neoplasms
      • Narcolepsy
      • Neoplasm Invasiveness
      • Ovarian cancer
      • Ovarian Neoplasms
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