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Millipore/FCMAB260PE | Milli-Mark? Anti-Notch 1-PE Antibody, clone mN1A/FCMAB260PE/100 tests
  • Millipore/FCMAB260PE | Milli-Mark? Anti-Notch 1-PE Antibody, clone mN1A/FCMAB260PE/100 tests

Millipore/FCMAB260PE | Milli-Mark? Anti-Notch 1-PE Antibody, clone mN1A/FCMAB260PE/100 tests

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貨號(hào): FCMAB260PE
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    • Description
      CatalogueNumberFCMAB260PE
      TradeName
      • Milli-Mark
      DescriptionMilli-Mark?Anti-Notch1-PEAntibody,clonemN1A
      BackgroundInformationThenotchgenebelongstoafamilyofepidermalgrowthfactor(EGF)likehomeoticgenes,whichencodetransmembraneproteinswithavariablenumberofcysteine-richEGF-likerepeatsintheextracellularregion.Fournotchgeneshavebeendescribedinmammals,whichincludenotch-1.notch-2,notch-3,andnotch-4(Int-3),whichhavebeenimplicatedinthedifferentiationofthenervoussystemandotherstructures.TheEGF-likeproteinsDeltaandSerratehavebeenidentifiedasligandsofnotch-1.Maturenotchproteinsareheterodimericreceptorsderivedfromthecleavageofnotchpre-proteinsintoanextracellularsubunit(NEC)containingmultipleEGF-likerepeatsandatransmembranesubunitincludingintracellularregion(Ntm).
      ProductInformation
      FormatPhycoerythrin
      Control
      • MouseThymocytes
      PresentationPurifiedmousemonoclonalIgG1conjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationMilli-MarkAnti-Notch1-PEAntibody,clonemN1AdetectslevelofNotch1&hasbeenpublished&validatedforuseinFC.
      KeyApplications
      • FlowCytometry
      BIOLOGicalInformation
      ImmunogenCdc10-NCRregionofmouseNotch1expressedasaGSTfusionprotein.
      Epitopeintracellulardomain
      CloneclonemN1A
      HostMouse
      SpecificityAntibodyrecognizesNotch1attheintracellulardomain
      IsotypeIgG1
      SpeciesReactivity
      • Mouse
      SpeciesReactivityNoteTestedandpassedonMouse.UnconjugatedPartNo.MAB5352isknowntoreactwithRatandFeline.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • NOTCH1
      • notch1
      • hN1
      • TAN1
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).

      SIZE:2556aminoacids;272500Da

      SUBUNIT:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.

      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).&Notch1intracellulardomain:Nucleus(Bysimilarity).Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity).

      TISSUESPECIFICITY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.

      PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).&Phosphorylated(Bysimilarity).

      DISEASE:SwissProt:P46531#NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.&DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.

      SIMILARITY:SwissProt:P46531##BelongstotheNOTCHfamily.&Contains5ANKrepeats.&Contains36EGF-likedomains.&Contains3LNR(Lin/Notch)repeats.
      MolecularWeight273kDaCalculated
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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