BackgroundInformation | CD71isa190kDadisulfide-bondedhomodimerictypeIItransmembraneglycoprotein.CD71isthereceptorfortransferrin.CD71isinvolvediniron(Fe3+)uptake,andexpressionisregulatedbythemetabolicdemandforiron,whichisessentialforthegrowingcell(Goding,2002).CD71ismoreabundantlyexpressedinrapidlydividingcellsthanquiescentcells(Newman,1982;Sutherland,1981).Innormaltissues,highexpressionofCD71isseenintheplacentaltrophoblastandhemoglobin-synthesizingreticulocytes(Newman,1982)butexpressionislostinmatureerythrocytes(Sutherland,1981).Anti-CD71,Ber-79,wasincludedintheFifthInternationalWorkshopandConferenceonHumanLeucocyteDifferentiationAntigens,andstudiesbyanumberoflaboratoriesconfirmeditsreactivitywithCD71(Boeker,1995). |