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Millipore/FCABS254F | Milli-Mark? Anti-EGFR-FITC Antibody/FCABS254F/100 tests
  • Millipore/FCABS254F | Milli-Mark? Anti-EGFR-FITC Antibody/FCABS254F/100 tests

Millipore/FCABS254F | Milli-Mark? Anti-EGFR-FITC Antibody/FCABS254F/100 tests

價(jià)格: ￥3204.00 市場(chǎng)價(jià): 5340.00
貨號(hào): FCABS254F
品牌: Millipore
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    • Description
      CatalogueNumberFCABS254F
      TradeName
      • Milli-Mark
      DescriptionMilli-Mark?Anti-EGFR-FITCAntibody
      AlternateNames
      • Receptortyrosine-proteinkinaseErbB-1
      • avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog
      • cellgrowthinhibitingprotein40
      • cellproliferation-inducingprotein61
      • epidermalgrowthfactorreceptor
      • epidermalgrowthfactorreceptor(avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog)
      • epidermalgrowthfactorreceptor(erythroblasticleukemiaviral(v-erb-b)oncogenehomolog,avian)
      BackgroundInformationTheepidermalgrowthfactorreceptor(EGFR;ErbB-1;HER1inhumans)isthecell-surfacereceptorformembersoftheepidermalgrowthfactorfamily(EGF-family)ofextracellularproteinligands.EGFRisamemberoftheErbBfamilyofreceptors,asubfamilyoffourcloselyrelatedreceptortyrosinekinases:EGFR(ErbB-1),HER2/c-neu(ErbB-2),Her3(ErbB-3)andHer4(ErbB-4).MutationsaffectingEGFRexpressionoractivitycouldresultincancer.EGFRexistsonthecellsurfaceandisactivatedbybindingofitsspecificligands,includingepidermalgrowthfactorandtransforminggrowthfactorα(TGFα).Uponactivationbyitsgrowthfactorligands,EGFRundergoesatransitionfromaninactivemonomericformtoanactivehomodimer.Inadditiontoforminghomodimersafterligandbinding,EGFRmaypairwithanothermemberoftheErbBreceptorfamily,suchasErbB2/Her2/neu,tocreateanactivatedheterodimer.EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivity.Asaresult,autophosphorylationoffivetyrosine(Y)residuesintheC-terminaldomainofEGFRoccurs.
      ProductInformation
      FormatFITC
      Control
      • A431cells
      PresentationPurifiedrabbitpolyclonalIgGconjugatedtoFITCinPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt
      Applications
      ApplicationMilli-MarkAnti-EGFR-FITCAntibodyisanantibodyagainstEGFRforuseinFC.
      KeyApplications
      • FlowCytometry
      BIOLOGicalInformation
      ImmunogenOvalbuminconjugatedsyntheticpeptidecorrespondingtoaminoacids1156-1186oftheprocessedmouseEGFreceptor(EGFR)C-terminaldomain(AccessionnumberQ01279).Theimmunizingsequenceshares28/31identitywiththehumanEGFreceptorsequence.
      HostRabbit
      SpecificityAntibodyrecognizeshumanEGFR
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.
      GeneSymbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST.

      SIZE:1210aminoacids;134277Da

      SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.

      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted.

      TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers.

      PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980].

      SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain.

      MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation.
      MolecularWeight134kDaCalculated
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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