Synonym:
5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt,
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt,
5-HCO-H4PteGlu,
Calcium folinate,
Citrovorum factor calcium salt,
Leucovorin calcium salt
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CAS Number 1492-18-8 (anhydrous)
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Empirical Formula (Hill Notation) C20H21CaN7O7 · xH2O
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Molecular Weight 511.50 (anhydrous basis)
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Beilstein Registry Number 5723924
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PubChem Substance ID 24894951
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Popular Documents: Specification Sheet (PDF)
Properties:
Related Categories |
Additional Drugs,
Analytical Standards,
Analytical/Chromatography,
Biochemicals and Reagents,
Coenzymes and Cofactors,
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grade
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analytical standard
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form
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neat
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application(s)
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HPLC: suitable
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gas chromatography (GC): suitable
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format
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neat
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Description:
Application
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Packaging
1 g in glass bottle
100, 500 mg in glass bottle
Safety:
Symbol
GHS07, GHS08
Hazard statements
H315-H317-H319-H334-H335
Precautionary statements
P261-P280-P305 + P351 + P338-P342 + P311
RIDADR
NONH for all modes of transport