UniProtSummary | FUNCTION:SwissProt:P02786#Cellularuptakeofironoccursviareceptor-mediatedendocytosisofligand-occupiedtransferrinreceptorintospecializedendosomes.Endosomalacidificationleadstoironrelease.Theapotransferrin-receptorcomplexisthenrecycledtothecellsurfacewithareturntoneutralpHandtheconcomitantlossofaffinityofapotransferrinforitsreceptor.Transferrinreceptorisnecessaryfordevelopmentoferythrocytesandthenervoussystem(Bysimilarity).Asecondligand,theheditaryhemochromatosisproteinHFE,competesforbindingwithtransferrinforanoverlappingC-terminalbindingsite. SIZE:760aminoacids;84871Da SUBUNIT:Homodimer;disulfide-linked.BindsonetransferrinorHFEmoleculepersubunit.BindstheHLAclassIIhistocompatibilityantigen,DR1.InteractswithSH3BP3. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeIImembraneprotein.Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV.&Transferrinreceptorprotein1,serumform:Secreted. PTM:N-andO-glycosylated,phosphorylatedandpalmitoylated.Theserumformisonlyglycosylated.&ProteolyticallycleavedonArg-100toproducethesolubleserumform(sTfR).&PalmitoylatedonbothCys-62andCys-67.Cys-62seemstobethemajorsiteofpalmitoylation. SIMILARITY:SwissProt:P02786##BelongstothepeptidaseM28family.M28Bsubfamily.&Contains1PA(proteaseassociated)domain. MISCELLANEOUS:Serumtransferrinreceptor(sTfR)isusedasameansofdetectingerythropoietin(EPO)misusebyathletesandasadiagnostictestforanemiaresultingfromanumberofconditionsincludingrheumatoidarthritis,pregnancy,irritablebowelsyndromeandinHIVpatients.&Canineandfelineparvovirusesbindhumanandfelinetransferrinreceptorsandusethesereceptorstoenterandinfectcells. |