Immunogen | PurifiedhumanTcells |
Clone | UCHT1 |
Host | Mouse |
Specificity | Thisantibodyrecognizes22/26/30kDamolecularweightlymphocytesurfacemoleculesassociatedwiththeTcellantigenreceptorcomplex.CD3iscloselyassociatedonthelymphocytecellsurfacewiththeTcellantigenreceptorTcR(2-4).ItisbelievedthattheCD3complextransmitsactivationalsignalstotheTcell"sinterioruponantigenrecognitionbyTcR.CD45(LCA),aproteintyrosinephosphatase,isapotentregulatorofsignaltransductionbytheCD3complex.ItreactswiththemajorityofperipheralbloodTlymphocytes,amajorproportionofthymocytes,themajorityofTcellchroniclymphocyticleukaemiacells,Sézaryleukaemiasandapproximately70%ofacutelymphoblasticleukaemiasofTcellorigin. Antigendistribution: Tcells100% PeripheralBloodlymphocytes75+7% Thymocytes68+5% Granulocytes<> Monocytes<> Bcells(E-)<> NKcells(CD16+)<> KNOWNSPECIESCROSSREACTIVITY:Negativewithrhesusmonkeyperipheralbloodleucocytesinflowcytometry FUSIONPARTNER:P3x63Ag8.653myelomacellline |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgeneistheCD3-epsilonpolypeptide,whichtogetherwithCD3-gamma,-deltaand-zeta,andtheT-cellreceptoralpha/betaandgamma/deltaheterodimers,formstheT-cellreceptor-CD3complex.Thiscomplexplaysanimportantroleincouplingantigenrecognitiontoseveralintracellularsignal-transductionpathways.Thegenesencodingtheepsilon,gammaanddeltapolypeptidesarelocatedinthesameclusteronchromosome11.TheepsilonpolypeptideplaysanessentialroleinT-celldevelopment.Defectsinthisgenecauseimmunodeficiency.ThisgenehasalsobeenlinkedtoasusceptibilitytotypeIdiabetesinwomen. |
GeneSymbol | |
Non-ReactiveSpecies | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P07766#TheCD3complexmediatessignaltransduction. SIZE:207aminoacids;23147Da SUBUNIT:TheTCR/CD3complexofT-lymphocytesconsistsofeitheraTCRalpha/betaorTCRgamma/deltaheterodimercoexpressedatthecellsurfacewiththeinvariantsubunitsofCD3labeledgamma,delta,epsilon,zeta,andeta. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P07766##Contains1Ig-like(immunoglobulin-like)domain.&Contains1ITAMdomain. |