Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases (class III HDACs) targeting multiple protein substrates. Sirtuin 2 (SIRT2) belongs to the family of Sir2 (Silent Information Regulator 2) proteins. Substrates for SIRT2 are not limited to histones but also include various transcription factors and co-regulators that modulate metabolic, cell cycle and cell death related pathways. Human SIRT2 is a cytoplasmic protein that increases in abundance during mitosis and regulates major events ofCytokinesis. This human recombinant SIRT2 is in its active form, and can be used forEnzyme activity assays.
Order #:
AS-72187
Unit Size:
10 μg
Supplier:
AnaSpec
Restrictions:
Only available in Germany and selected European countries.