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Millipore/ABN27 | Anti-GRIP-1 Antibody, CT/ABN27/100 µg
  • Millipore/ABN27 | Anti-GRIP-1 Antibody, CT/ABN27/100 µg

Millipore/ABN27 | Anti-GRIP-1 Antibody, CT/ABN27/100 µg

價格: ￥4188.00 市場價: 6980.00
貨號: ABN27
品牌: Millipore
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    • Description
      CatalogueNumberABN27
      Replaces06-986
      DescriptionAnti-GRIP-1Antibody,CT
      AlternateNames
      • glutamatereceptorinteractingprotein1
      • glutamatereceptor-interactingprotein1
      BackgroundInformationGlutamatereceptorinteractingprotein-1(GRIP-1)isamulti-PDZdomainscaffoldproteinandamemberofthesteroidreceptorcoactivator(SRC)familyofproteins.GRIP-1interactsandmaneuverskinesinheavychainstodendritesbyactingasthepowersourceforAMPAreceptors.Duringinitialstagesofembryonicdevelopment,GRIP-1isessentialfortypicalcell-matrixinteractions.
      ProductInformation
      FormatAffinityPurified
      Control
      • Ratbraincytosoltissuelysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationDetectGRIP-1usingthisAnti-GRIP-1Antibody,C-terminusvalidatedforuseinWB,IP,IH(P).
      KeyApplications
      • WesternBlotting
      • Immunoprecipitation
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunoprecipitationAnalysis:10μgfromapreviouslotimmunoprecipitatedGRIP-1fromratbraincytosoltissuelysate.

      ImmunohistochemistryAnalysis:1:300dilutionfromapreviouslotdetectedGRIP-1inratbraincells.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheC-terminusofratGRIP-1.
      EpitopeC-terminus
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesGRIP-1attheC-terminus.
      SpeciesReactivity
      • Rat
      • Human
      • Mouse
      • Chimpanzee
      SpeciesReactivityNoteDemonstratedtoreactwithrat.Predictedtoreactwithhuman,mouse,andchimpanzeebasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryBindstotheliprin-alphaSVD2familyofproteinstomediatesynaptictargetingofAMPAreceptors;mayplayaroleinpresynapticandpostsynapticmaturation[RGD].
      GeneSymbol
      • GRIP
      • GRIP-1
      • GRIP1
      • CT
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Mayplayaroleasalocalizedscaffoldfortheassemblyofamultiproteinsignalingcomplexandasmediatorofthetraffickingofitsbindingpartnersatspecificsubcellularlocationinneurons.

      SUBUNITSTRUCTURE:InteractswithEFNB1,EPHA7,EPHB2,EFNB3,KIF5A,KIF5C,KIF5BandtheC-terminaltailofPRLHR.FormsaternarycomplexwithGRIA2andCSPG4(Bysimilarity).CanformhomomultimersorheteromultimerswithGRIP2.InteractswithGRIA2,GRIA3,GRIPAP1/GRASP1,PPFIA1,PPFIA4,FRAS1,PLCD4,PTPRFandliprins-alpha.InteractswithSLC30A9(Bysimilarity).

      SUBCELLULARLOCATION:Cytoplasm.Endomembranesystem;Peripheralmembraneprotein.Celljunction?synapse?postsynapticcellmembrane.Celljunction?synapse?postsynapticcellmembrane?postsynapticdensity.Endoplasmicreticulummembrane;Peripheralmembraneprotein(Potential).Note:Membrane-associatedwithvesicles,peri-Golgicomplexesandendoplasmicreticulum.Enrichedinpost-synapticplasmamembraneandpost-synapticdensities.

      TISSUESPECIFICTY:Expressedinbrain,testisandretina.Inbrainhighlyexpressedintheolfactorybulb,cortexandhyppocampusandlowerlevelinthalamus,cerebellumandspinalcord.Inbrainitisfoundintheperikaryon,dendrites,dendriticshafts,dendriticspinesand,excitatoryandinhibitorysynapsesofneurons.Inretina,itismostabundantintheplexiformlayersthaninperikarya.

      DEVELOPMENTALSTAGE:DetectedinearlyembryonicstageasearlyasE15,graduallyincreasedthroughoutearlydevelopment,peakedatapproximatelybetweenpostnataldaysP6andP8,thenslightlydecreasedandremainedrelativelystableintheadult.

      DOMAIN:PDZ6mediatesinteractionwiththePDZrecognitionmotifofEFNB1andEPHB2andwiththeC-terminusofPPFIA1andPPFIA4.PDZ4andPDZ5mediateinteractionwithPRLHR(Bysimilarity).PDZ4andPDZ5mediateinteractionwiththeC-terminusofGRIA2andGRIA3.PDZ4,PDZ5andPDZ6mediatehomomultimers.PDZ7mediatesinteractionwithPDZdomainofGRASP1.PDZ7domainbindsCSPG4.PDZ6mediatesinteractionwiththeC-terminusofliprins-alpha.PDZ1,PDZ2andPDZ3mediateinteractionwiththePDZ-bindingmotifofFRAS1.

      SEQUENCESIMILARITIES:Contains7PDZ(DHR)domains.
      MolecularWeight~121kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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