BackgroundInformation | Neuropilin-1(NRP1),alsoknownasVascularendothelialcellgrowthfactor165receptor(VEGF165R),isatype1membraneproteinwiththreedistinctfunctions.First,itcanmediatecelladhesionviaaheterophilicmolecularinteraction.Second,inneuronalcells,neuropilin-1bindstheclass3semaphorins,whichareneuronalchemorepellents,andplaysaroleinthedirectionalguidanceofaxons.ItisexpectedtoformcomplexeswiththeplexinAsubfamilymembersandmediatethesemaphorin-elicitedinhibitorysignalsintoneurons.Third,inendothelialcells,neuropilin-1bindsapotentendothelialcellmitogen,vascularendothelialgrowthfactor(VEGF)165,andregulatesvesselformation. |