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Millipore/ABE257 | Anti-RAD51 Antibody/ABE257/100 µL
  • Millipore/ABE257 | Anti-RAD51 Antibody/ABE257/100 µL

Millipore/ABE257 | Anti-RAD51 Antibody/ABE257/100 µL

價格: ￥3324.00 市場價: 5540.00
貨號: ABE257
品牌: Millipore
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    • Description
      CatalogueNumberABE257
      ReplacesMABE515
      DescriptionAnti-RAD51Antibody
      AlternateNames
      • DNArepairproteinRAD51homolog1
        Shortname=HsRAD51
        Shortname=hRAD51
        Alternativename(s):
        RAD51homologA
      BackgroundInformationRAD51isessentialforhomologousrecombinationofDNAduringrepairofdouble-strandbreaks.TheN-terminusofRAD51functionstobindDNAandpromotehomologouspairingandstrandexchangewithinaregularnucleoproteinfilament.Inyeast,theRad51familyofrelatedproteinsalsoincludesRad55,Rad57,andDmc1.Inmammaliancells,sevengenesinthisfamilyhavebeenidentified(HsRAD51,XRCC2,XRCC3,RAD51B/hREC2andHsDMC1,RAD51C,andRAD51D).RAD51ispredominantlyexpressedinthetestisandthymusbutcanalsobefoundinthesmallintestine,placenta,colon,pancreasandovaries.
      ProductInformation
      FormatAffinityPurified
      Control
      • HeLacelllysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-RAD51AntibodyisaRabbitPolyclonalAntibodyfordetectionofRAD51alsoknownasDNArepairproteinRAD51homolog1,HsRAD51&hasbeenvalidatedinWB,ICC&IP.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • Immunoprecipitation
      ApplicationNotesImmunocytochemistryAnalysis:1:500dilutionfromarepresentativelotdetectedRAD51inA431andHeLacells.

      ImmunoprecipitationAnalysis:40μLofAnti-RAD51immunoprecipitatedRAD51fromHeLaRIPAlysate.
      BIOLOGicalInformation
      ImmunogenHistidine-taggedrecombinantproteincorrespondingtohumanRAD51.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithHuman,Mouse,andRat.Otherhomologies:Bovine,Equine,andCanine(99%sequencehomology).
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheRAD51proteinfamily.RAD51familymembersarehighlysimilartobacterialRecAandSaccharomycescerevisiaeRad51,andareknowntobeinvolvedinthehomologousrecombinationandrepairofDNA.ThisproteincaninteractwiththessDNA-bindingproteinRPAandRAD52,anditisthoughttoplayrolesinhomologouspairingandstrandtransferofDNA.ThisproteinisalsofoundtointeractwithBRCA1andBRCA2,whichmaybeimportantforthecellularresponsetoDNAdamage.BRCA2isshowntoregulateboththeintracellularlocalizationandDNA-bindingABIlityofthisprotein.LossofthesecontrolsfollowingBRCA2inactivationmaybeakeyeventleADIngtogenomicinstabilityandtumOrigenesis.Multipletranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq].
      GeneSymbol
      • RAD51
      • RAD51A
      • RECA
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:MayparticipateinacommonDNAdamageresponsepathwayassociatedwiththeactivationofhomologousrecombinationanddouble-strandbreakrepair.BindstosingleanddoublestrandedDNAandexhibitsDNA-dependentATPaseactivity.UnderwindsduplexDNAandformshelicalnucleoproteinfilaments.PlaysaroleinregulatingmitochondrialDNAcopynumberunderconditionsofoxidativestressinthepresenceofRAD51CandXRCC3.

      SUBUNITSTRUCTURE:InteractswithBRCA1,BRCA2andeitherdirectlyorindirectlywithp53.InteractswithXRCC3,RAD54LandRAD54B.PartofacomplexwithRAD51CandRAD51B.InteractswithRAD51AP1andRAD51AP2.InteractswithCHEK1/CHK1,andthismayrequirepriorphosphorylationofCHEK1.InteractswiththeMND1-PSMC3IPheterodimer(Bysimilarity).InteractswithOBFC2B.InteractswithRPA1.InteractswithPALB2.InteractswithSWI5/C9orf119,andatlowerlevelwithSFR1/MEIR5.

      SUBCELLULARLOCATION:Nucleus.Cytoplasm.Cytoplasm?perinuclearregion.Mitochondrionmatrix.Note:ColocalizeswithRAD51AP1tomultiplenuclearfociuponinductionofDNAdamage.DNAdamageinducesanincreaseinnuclearlevels.

      TISSUESPECIFICITY:Highlyexpressedintestisandthymus,followedbysmallintestine,placenta,colon,pancreasandovary.Weaklyexpressedinbreast.

      INDUCTION:Stress-inducedincreaseinthemitochondriallevelsisseen.

      PTM:Phosphorylated.PhosphorylationofThr-309byCHEK1/CHK1mayenhanceassociationwithchromatinatsitesofDNAdamageandpromoteDNArepairbyhomologousrecombination.

      INVOLVEMENTINDISEASE:DefectsinRAD51areacauseofsusceptibilitytobreastcancer(BC)[MIM:114480].Acommonmalignancyoriginatingfrombreastepithelialtissue.Breastneoplasmscanbedistinguishedbytheirhistologicpattern.Invasiveductalcarcinomaisbyfarthemostcommontype.Breastcancerisetiologicallyandgeneticallyheterogeneous.Importantgeneticfactorshavebeenindicatedbyfamilialoccurrenceandbilateralinvolvement.Mutationsatmorethanonelocuscanbeinvolvedindifferentfamiliesoreveninthesamecase.Ref.28

      SEQUENCESIMILARITIES:BelongstotheRecAfamily.RAD51subfamily.

      Contains1HhHdomain.
      MolecularWeight~37kDaobserved.Twoisoforms(isoform1at37kDaandisoform2at26kDa)producedasaresultofalternativesplicingareknowntoexist:.
      PhysicochemicalInformation
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      MaterialsInformation
      MaterialsInformation
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