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Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg
  • Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg

Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg

價(jià)格: ￥3696.00 市場(chǎng)價(jià): 6160.00
貨號(hào): ABE208
品牌: Millipore
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    • Description
      CatalogueNumberABE208
      Replaces04-1002
      DescriptionAnti-β-CateninAntibody
      AlternateNames
      • catenin(cadherin-associatedprotein),beta1,88kDa
      • catenin(cadherin-associatedprotein),beta1(88kD)
      BackgroundInformationβ-cateninisthefoundingmemberoftheβ-cateninfamily.Thisproteiniscomprisedof12ARMrepeatsandisconsideredtohavedualfunctiondependingonitslocalization.Cytoplasmicβ-cateninisacriticalcomponentofE-cadherin/cateningadhesioncomplexesandisinvolvedinregulatingcadherin-dependentcell-cellinteractions.Whenlocalizedtothenucleus,β-cateninservesaregulatoryrolebybindingwithtranscriptionfactorsfromtheTCF/LEFfamily,activatingtranscription.Expressionofβ-cateninhasbeenreportedinavarietyofhairfolliclecellssuchascellsfoundintheinnerandouterportionsoftherootsheaths,andthebasalandperipheralmatrixcells.Ithasalsobeenobservedincolontissue.Defectsinexpressionhavebeenlinkedtothedevelopmentofseveraltumorsandcancerssuchas;colorectalcancer(CRC),medulloblastoma(MDB),ovariancancer(OC),andpilomatrixoma(PTR).
      ProductInformation
      FormatAffinityPurified
      Control
      • A431celllysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-β-CateninAntibodyisaRabbitPolyclonalAntibodyfordetectionofβ-Cateninalsoknownascatenin(cadherin-associatedprotein)beta1(88kD)&hasbeenvalidatedinWB,ICC&IP.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • Immunoprecipitation
      ApplicationNotesImmunoprecipitationAnalysis:10μgfromarepresentativelotimmunoprecipitatedβ-CateninfromA431lysate.

      ImmunocytochemistryAnalysis:1:500dilutionfromarepresentativelotdetectedβ-CatenininNIH/3T3andA431cells.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheconsensusGSK3phosphorylationsiteofhumanβ-Catenin.
      EpitopeConsensusGSK3phosphorylationsiteofhumanβ-Catenin
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityAntibodyrecognizesβ-CateninattheN-terminus.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Horse
      • Ox
      SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithequineandoxbasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneispartofacomplexofproteinsthatconstituteadherensjunctions(AJs).AJsarenecessaryforthecreationandmaintenanceofepithelialcelllayersbyregulatingcellgrowthandadhesionbetweencells.TheencodedproteinalsoanchorstheactinCytoskeletonandmayberesponsIBLefortransmittingthecontactinhibitionsignalthatcausescellstostopdividingoncetheepithelialsheetiscomplete.Finally,thisproteinbindstotheproductoftheAPCgene,whichismutatedinadenomatouspolyposisofthecolon.Mutationsinthisgeneareacauseofcolorectalcancer(CRC),pilomatrixoma(PTR),medulloblastoma(MDB),andovariancancer.Threetranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene.
      GeneSymbol
      • CTNNB1
      • CTNNB
      • Beta-catenin
      • PRO2286
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.

      SIZE:781aminoacids;85497Da

      SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossiblyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2.InteractswithSLC30A9(Bysimilarity).

      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2promotesnucleartranslocation.

      TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.

      PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33.&EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding.&UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1X(Probable).Itsubiquitinationleadstoitssubsequentproteasomaldegradation.

      DISEASE:ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife.&DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor.&DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren.&AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1."

      SIMILARITY:Belongstothebeta-cateninfamily.&Contains12ARMrepeats.
      MolecularWeight~86kDaobserved.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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