Immunogen | Syntheticpeptidefromthecentralregionofhumansemaphorin3A. |
Host | Rabbit |
Specificity | Semaphorin3A.Theimmunogensequencehaslowhomologywithothersemaphorinfamilymembers. |
SpeciesReactivity | |
SpeciesReactivityNote | Itisexpectedthattheantibodywillalsoreactwithmouse. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneisamemberofthesemaphorinfamilyandencodesaproteinwithanIg-likeC2-type(immunoglobulin-like)domain,aPSIdomainandaSemadomain.Thissecretedproteincanfunctionaseitherachemorepulsiveagent,inhibitingaxonaloutgrowth,orasachemoattractiveagent,stimulatingthegrowthofapicaldendrites.Inbothcases,theproteinisvitalfornormalneuronalpatterndevelopment.Increasedexpressionofthisproteinisassociatedwithschizophreniaandisseeninavarietyofhumantumorcelllines.Also,aberrantreleaseofthisproteinisassociatedwiththeprogressionofAlzheimer"sdisease. |
GeneSymbol | - SEMA3A
- SEMAD
- SEMAIII
- SEMA1-PEN
- semaphorin-like
- MGC133243
- SEMA1
- Hsema-I
- Hsema-III
- SemD
- coll-1
- SEMAL
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q14563#Inducesthecollapseandparalysisofneuronalgrowthcones.Couldserveasaligandthatguidesspecificgrowthconesbyamotility-inhibitingmechanism.Bindstothecomplexneuropilin-1/plexin-1(Bysimilarity). SIZE:771aminoacids;88889Da SUBCELLULARLOCATION:Secreted(Bysimilarity). DOMAIN:SwissProt:Q14563Strongbindingtoneuropilinismediatedbythecarboxythirdoftheprotein. SIMILARITY:Belongstothesemaphorinfamily.&Contains1Ig-likeC2-type(immunoglobulin-like)domain.&Contains1PSIdomain.&Contains1Semadomain. |