Immunogen | Syntheticpeptide. |
Host | Rabbit |
Specificity | ReactswithSodiumPump(Na+pump(Na+-K+-ATPase))alpha2isoform.TheantibodydoesnotcrossreactwithotherNa+-K+-ATPasealphaisoforms. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgenebelongstothefamilyofP-typecationtransportATPases,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).ThecatalyticsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesanalpha2subunit. |
GeneSymbol | - ATP1A2
- FHM2
- MGC59864
- KIAA0778
- MHP2
- +K
- Na
- EC3.6.3.9
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P50993#Thisisthecatalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofsodiumandpotassiumionsacrosstheplasmamembrane.Thisactioncreatestheelectrochemicalgradientofsodiumandpotassium,providingtheenergyforactivetransportofvariousnutrients. SIZE:1020aminoacids;112265Da SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. DISEASE:SwissProt:P50993#DefectsinATP1A2arethecauseoffamilialhemiplegicmigraine2(FHM2)[MIM:602481].Familialhemiplegicmigraineisarare,severe,autosomaldominantsubtypeofmigrainecharacterizedbyauraandsomehemiparesis.&DefectsinATP1A2areacauseofalternatinghemiplegiaofchildhood(AHC)[MIM:104290].AHCistypicallydistinguishedfromfamilialhemiplegicmigrainebyinfantileonsetofthesymptomsandhighprevalenceofassociatedneurologicaldeficitsthatbecomeincreasinglyobviouswithage. SIMILARITY:SwissProt:P50993##BelongstothecationtransportATPase(P-type)family.TypeIICsubfamily. |