Immunogen | SyntheticpeptidefromthephosphoSer40ofratTyrosineHydroxylase. |
Epitope | phospho-Ser40 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | TyrosineHydroxylase,phosphoSer40.Theantibodyrecognizesaproteinof60kDacorrespondingtoTHphosphorylatedatSer40.Dependingonbrainregionbeingstudied,proteinloadsanddetectionmethodsusedsomehighermolecularweightbandsmaybedetected. |
SpeciesReactivity | |
SpeciesReactivityNote | Ratandmouse.Itisexpectedthattheantibodywillalsoreactwithhuman,porcine,quailandnon-humanprimatesduetosequencehomology(100%).Otherspecieshavenotbeentested. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
GeneSymbol | |
Modifications | |
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
MolecularWeight | 60kDa |