Immunogen | SyntheticpeptidefromratVGLUT1proteinwithnooverlaptoVGLUT2.TheimmunogenisavailableasAG208. |
Concentration | Variable |
Host | GuineaPig |
Specificity | RecognizesVesicularGlutamateTransporter1(VGLUT1,BNPI{BrainspecificNa+dependentinorganicphosphatecotransporter}).Theantiserumhasbeentestedontissuesectionsfromtheratcentralnervoussystem(CNS)usingimmunofluorescencehistochemistry.Theantiserummainlylabelsnervefibersandterminals.VGLUT1isanexcellentMarkerforglutamatergicnerveterminals.ThestainingpatternforthestainingobtainedwiththeVGLUT1antiserumcorrespondstothepatterndescribedusingotherantiseratoVGLUT1(Bellocchioetal.,1998;Fremeauetal.,2001;Fujiyamaetal.,2001;Sakata-Hagaetal.,2001;Tongetal.,2001;Kanekoetal.2002;Varoquietal.,2002).PreabsorptionoftheVGLUT1antiserumwithimmunogenpeptideeliminatesallimmunostaining. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | aNa(+)-dependentinorganicphosphatecotransporter. |
GeneSymbol | - VGluT1
- Solutecarrierfamily17member7
- Brain-specificNa(+)-dependentinorganicphosphatecotransporter
- Slc17a7
- Bnpi
|
PurificationMethod | Unpurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Mediatestheuptakeofglutamateintosynapticvesiclesatpresynapticnerveterminalsofexcitatoryneuralcells.Mayalsomediatethetransportofinorganicphosphate. SIZE:560aminoacids;61665Da[MWofunprocessedprecursor] SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane.Membrane;Multi-passmembraneprotein(Potential).Celljunction,synapse,synaptosome. TISSUESPECIFICITY:Expressedinthecerebellum,cerberalcortexandhippocampus.Isoform2isexpressedspecificallyinretina. SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sodium/anioncotransporterfamily.VGLUTsubfamily. |
MolecularWeight | 62kDa |