Immunogen | GSTfusionproteincorrespondingtoacytoplasmic,N-terminalpartofratormouseVAMP-2(AccessionnumbersQ64357,NP036795). |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesVAMP-2(Vesicle-AssociatedMembraneProtein2,Synaptobrevin2).Theepitopedoesnotsharehomologywithanyotherknownproteins.
SPECIESREACTIVITIES:Itisexpectedthattheantibodywillalsoreactwithhuman,Macacamultataandbovineduetosequencehomology(25/26).Otherspecieshavenotbeentested. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthevesicle-associatedmembraneprotein(VAMP)/synaptobrevinfamily.Synaptobrevins/VAMPs,syntaxins,andthe25-kDsynaptosomal-associatedproteinSNAP25arethemaincomponentsofaproteincomplexinvolvedinthedockingand/orfusionofsynapticvesicleswiththepresynapticmembrane.Thisgeneisthoughttoparticipateinneurotransmitterreleaseatastepbetweendockingandfusion.Theproteinformsastablecomplexwithsyntaxin,synaptosomal-associatedprotein,25kD,andsynaptotagmin.Italsoformsadistinctcomplexwithsynaptophysin.Itisalikelycandidategeneforfamilialinfantilemyasthenia(FIMG)becauseofitsmaplocationandbecauseitencodesasynapticvesicleproteinofthetypethathasbeenimplicatedinthepathogenesisofFIMG. |
GeneSymbol | - VAMP2
- VAMP-2
- FLJ11460
- Synaptobrevin-2
- SYB2
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P63027#Involvedinthetargetingand/orfusionoftransportvesiclestotheirtargetmembrane. SIZE:116aminoacids;12649Da SUBUNIT:InteractswithVAPAandVAPB. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Single-passtypeIVmembraneprotein.Note=Neuronalsynapticvesicles. TISSUESPECIFICITY:Nervoussystemandskeletalmuscle. SIMILARITY:SwissProt:P63027##Belongstothesynaptobrevinfamily.&Contains1v-SNAREcoiled-coilhomologydomain. |