UniProtSummary | FUNCTION:SwissProt:Q9Y566#Seemstobeanadapterproteininthepostsynapticdensity(PSD)ofexcitatorysynapsesthatinterconnectsreceptorsofthepostsynapticmembraneincludingNMDA-typeandmetabotropicglutamatereceptorsviacomplexeswithGKAP/PSD-95andHomer,respectively,andtheactin-basedcytoskeleton.Mayplayaroleinthestructuralandfunctionalorganizationofthedendriticspineandsynapticjunction. SIZE:2161aminoacids;225021Da SUBUNIT:MayhomomultimerizeviaitsSAMdomain(Bysimilarity).InteractswiththeC-terminusofSSTR2viathePDZdomain.InteractswithIGSF9,SHARPIN,SPTAN1,HOMER1andDLGAP1/GKAPisoforms1and2(Bysimilarity).PartofacomplexwithDLG4/PSD-95andDLGAP1/GKAP(Bysimilarity).InteractswithBAIAP2. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity(Bysimilarity).Celljunction,synapse(Bysimilarity).Note=Postsynapticdensityofneuronalcells(Bysimilarity).TISSUESPECIFICITY:Expressedinbrainparticularlyintheamygdala,hippocampus,substantianigraandthalamus.Isoform2seemstobeexpressedubiquitously. SIMILARITY:SwissProt:Q9Y566##BelongstotheSHANKfamily.&Contains6ANKrepeats.&Contains1PDZ(DHR)domain.&Contains1SAM(sterilealphamotif)domain.&Contains1SH3domain. |