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Millipore/AB5729 | Anti-Noggin Antibody/AB5729/100 µg
  • Millipore/AB5729 | Anti-Noggin Antibody/AB5729/100 µg

Millipore/AB5729 | Anti-Noggin Antibody/AB5729/100 µg

價(jià)格: ￥3948.00 市場(chǎng)價(jià): 6580.00
貨號(hào): AB5729
品牌: Millipore
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    • Description
      CatalogueNumberAB5729
      ReplacesMABD184
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NogginAntibody
      ProductInformation
      FormatAffinityPurified
      PresentationAffinitypurifiedimmunoglobulin.Liquid.
      StorageandShippingInformation
      StorageConditionsMaintainat+2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.
      Applications
      ApplicationDetectNogginusingthisAnti-NogginAntibodyvalidatedforuseinWB.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternblot:0.5-1.0μg/mLusingECLonrecombinantmaturemouseNoggin/Fc.Theantibodyreactswiththepredicted55-60kDarecombinantprotein.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidefrommouseNoggin.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityNoggin,mouse.
      SpeciesReactivity
      • Mouse
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThesecretedpolypeptide,encodedbythisgene,bindsandinactivatesmembersofthetransforminggrowthfactor-beta(TGF-beta)superfamilysignalingproteins,suchasbonemorphogeneticprotein-4(BMP4).BydiffusingthroughextracellularmatricesmoreefficientlythanmembersoftheTGF-betasuperfamily,thisproteinmayhaveaprincipalroleincreatingmorphogenicgrADIents.Theproteinappearstohavepleiotropiceffect,bothearlyindevelopmentaswellasinlaterstages.ItwasoriginallyisolatedfromXenopusbasedonitsABIlitytorestorenormaldorsal-ventralbodyaxisinembryosthathadbeenartificiallyventralizedbyUVtreatment.Theresultsofthemouseknockoutoftheorthologsuggestthatitisinvolvedinnumerousdevelopmentalprocesses,suchasneuraltubefusionandjointformation.Recently,severaldominanthumanNOGmutationsinunrelatedfamilieswithproximalsymphalangism(SYM1)andmultiplesynostosessyndrome(SYNS1)wereidentified;bothSYM1andSYNS1havemultiplejointfusionastheirprincipalfeature,andmaptothesameregion(17q22)asthisgene.Allofthesemutationsalteredevolutionarilyconservedaminoacidresidues.TheaminoacidsequenceofthishumangeneishighlyhomologoustothatofXenopus,ratandmouse.
      GeneSymbol
      • NOG
      • SYNS1
      • SYM1
      • noggin
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q13253#Essentialforcartilagemorphogenesisandjointformation.Inhibitorofbonemorphogeneticproteins(BMP)signalingwhichisrequiredforgrowthandpatterningoftheneuraltubeandsomite(Bysimilarity).
      SIZE:232aminoacids;25774Da
      SUBUNIT:Homodimer;disulfide-linked(Bysimilarity).
      SUBCELLULARLOCATION:Secreted.
      DISEASE:SwissProt:Q13253#DefectsinNOGarethecauseofsymphalangismproximalsyndrome(SYM1)[MIM:185800].SYM1ischaracterizedbythehereditaryabsenceoftheproximalinterphalangeal(PIP)joints(Cushingsymphalangism).SeverityofPIPjointinvolvementdiminishestowardstheradialside.Distalinterphalangealjointsarelessfrequentlyinvolvedandmetacarpophalangealjointsarerarelyaffectedwhereascarpalbonemalformationandfusionarecommon.Inthelowerextremities,tarsalbonecoalitioniscommon.Conducivehearinglossisseenandisduetofusionofthestapestothepetrouspartofthetemporalbone.&DefectsinNOGarethecauseofmultiplesynostosessyndrome1(SYNS1)[MIM:186500];alsoknownassynostoses,multiple,withbrachydactyly/symphalangism-brachydactylysyndrome.SYNS1ischaracterizedbytubular-shaped(hemicylindrical)nosewithlackofalarflare,otoscleroticdeafness,andmultipleprogressivejointfusionscommencinginthehand.Thejointfusionsareprogressive,commencinginthefifthproximalinterphalangealjointinearlychildhood(oratbirthinsomeindividuals)andprogressinginanulnar-to-radialandproximal-to-distaldirection.Withincreasingage,ankylosisofotherjoints,includingthecervicalvertebrae,hips,andhumeroradialjoints,develop.&DefectsinNOGarethecauseoftarsal-carpalcoalitionsyndrome(TCC)[MIM:186570].TCCisanautosomaldominantdisordercharacterizedbyfusionofthecarpals,tarsalsandphalanges,shortfirstmetacarpalscausingbrachydactyly,andhumeroradialfusion.TCCisallelictoSYM1,anddifferentmutationsinNOGcanresultineitherTCCorSYM1indifferentfamilies.&DefectsinNOGareacauseofstapesankylosiswithbroadthumbandtoes[MIM:184460].Stapesankylosiswithbroadthumbandtoesisacongenitalautosomaldominantdisorderthatincludeshyperopia,ahemicylindricalnose,broadthumbs,greattoes,andotherminorskeletalanomaliesbutlackedcarpalandtarsalfusionandsymphalangism.&DefectsinNOGarethecauseofbrachydactylytypeB2(BDB2)[MIM:611377].BDB2isasubtypeofbrachydactylycharacterizedbyhypoplasia/aplasiaofdistalphalangesincombinationwithdistalsymphalangism,fusionofcarpal/tarsalbones,andpartialcutaneoussyndactyly.
      SIMILARITY:SwissProt:Q13253##Belongstothenogginfamily.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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