Immunogen | PurifiedMicrotubule-associatedproteinfromratbrain. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | SpecificforMicrotubule-associatedprotein2(MAP2).TheantibodyrecognizesallMAP2isoforms(MAP2A,MAP2B,MAP2CandMAP2D).ItshowsgreatestimmunoreactivitywiththeHMW-MAP2(MAP2AandMAP2B). |
SpeciesReactivity | |
SpeciesReactivityNote | Human,mouseandrat.Reactivitywithotherspecieshasnotbeendetermined. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesaproteinthatbelongstothemicrotubule-associatedproteinfamily.Theproteinsofthisfamilyarethoughttobeinvolvedinmicrotubuleassembly,whichisanessentialstepinneurogenesis.Theproductsofsimilargenesinratandmouseareneuron-specificcytoskeletalproteinsthatareenrichedindentrites,implicatingaroleindeterminingandstabilizingdentriticshapeduringneurondevelopment.Anumberofalternativelysplicedvariantsencodingdistinctisformshavebeendescribed. |
GeneSymbol | - MAP2
- MAP2B
- MAP-2
- MAP2C
- DKFZp686I2148
- MAP2A
|
PurificationMethod | AmmoniumSulfatePrecipitation |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P11137#TheexactfunctionofMAP2isunknownbutMAPsmaystabilizethemicrotubulesagainstdepolymerization.Theyalsoseemtohaveastiffeningeffectonmicrotubules. SIZE:1827aminoacids;199539Da PTM:MAP2A/cisphosphorylated.PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P11137##Contains3Tau/MAPrepeats. |
MolecularWeight | Approx.280kDadoublet(MAP2aandMAP2b)andapprox.70kDadoublet(MAP2c)onSDS-PAGE. |