UniProtSummary | FUNCTION:SwissProt:Q9Y3R0#Mayplayaroleasalocalizedscaffoldfortheassemblyofamultiproteinsignalingcomplexandasmediatorofthetraffickingofitsbindingpartnersatspecificsubcellularlocationinneurons. SIZE:1128aminoacids;122423Da SUBUNIT:InteractswithEPHA7,EPHB2,KIF5A,KIF5B,KIF5C,GRIA2,GRIA3,GRIPAP1/GRASP1,PPFIA1,PPFIA4,FRAS1,PLCD4,PTPRFandliprins-alpha.CanformhomomultimersorheteromultimerswithGRIP2.FormsaternarycomplexwithGRIA2andCSPG4(Bysimilarity).InteractswithEFNB1,EFNB3andtheC-terminaltailofPRLHR.InteractswithSLC30A9(Bysimilarity). SUBCELLULARLOCATION:Cytoplasmicvesicle.Endoplasmicreticulum.Celljunction,synapse,postsynapticcellmembrane(Bysimilarity).Note=Cytoplasmicandmembrane-associatedwithvesicles,peri-Golgicomplexesandendoplasmicreticulum.Enrichedinpost-synapticplasmamembraneandpost-synapticdensities(Bysimilarity). DOMAIN:"SwissProt:Q9Y3R0PDZ6mediatesinteractionwiththePDZrecognitionmotifofEFNB1andEPHB2andwiththeC-terminusofPPFIA1andPPFIA4.PDZ4andPDZ5mediateinteractionwiththeC-terminusofGRIA2andGRIA3.PDZ4,PDZ5andPDZ6mediatehomomultimers.PDZ7mediatesinteractionwithPDZdomainofGRASP1.PDZ7domainbindsCSPG4.PDZ6mediatesinteractionwiththeC-terminusofliprins-alpha.PDZ1,PDZ2andPDZ3mediateinteractionwiththePDZ-bindingmotifofFRAS1(Bysimilarity).PDZ4andPDZ5mediateinteractionwithPRLHR. SIMILARITY:Contains7PDZ(DHR)domains. |