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Millipore/AB1876 | Anti-Vascular Endothelial Growth Factor Antibody/AB1876/100 µg
  • Millipore/AB1876 | Anti-Vascular Endothelial Growth Factor Antibody/AB1876/100 µg

Millipore/AB1876 | Anti-Vascular Endothelial Growth Factor Antibody/AB1876/100 µg

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貨號: AB1876
品牌: Millipore
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    • Description
      CatalogueNumberAB1876
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-VascularEndothelialGrowthFactorAntibody
      AlternateNames
      • VEGF
      ProductInformation
      FormatPurified
      PresentationImmunoglobulinpurifiedbyHPLC.Liquid(sterilefiltered)withnopreservatives.
      StorageandShippingInformation
      StorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-VascularEndothelialGrowthFactorAntibodyisanantibodyagainstVascularEndothelialGrowthFactorforuseinELISA&WB.
      KeyApplications
      • ELISA
      • WesternBlotting
      ApplicationNotesWesternblot:1:100-1:1,000

      ELISA:1:100-1:1,000

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenRecombinantmouseVEGF.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityReactswithmouseVEGF.Nocross-reactivitywithWHOstandardstoanextensivepanelofcytokinesandgrowthfactorsbyEIA.
      SpeciesReactivity
      • Mouse
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeABIlity,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.
      GeneSymbol
      • VEGFA
      • VPF
      • VEGF-A
      • MGC70609
      • VEGF
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P15692#Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.
      SIZE:232aminoacids;27042Da
      SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity).
      SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin.
      TISSUESPECIFICITY:TheVEGF189,VEGF-165andVEGF-121isoformsarewidelyexpressed,whereastheVEGF206andVEGF-145areuncommon.
      SIMILARITY:SwissProt:P15692##BelongstothePDGF/VEGFgrowthfactorfamily.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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