Immunogen | Raisedagainsta12aminoacidsequencecorrespondingtotheN-terminusofthehumanvascularendothelialgrowthfactorreceptor3[VEGFR3/FLT4]. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | AB1875isspecificfortheN-terminusofVEGFReceptor3[FLT4]and,thus,itwillrecognizeboththelongandshortformsofthereceptor.Stainingofformalinfixedparaffinembeddedhumantissuesectionsispredominantlylocalizedinthecytoplasm. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | - FLT4
- PCL
- VEGFR-3
- FLT41
- VEGFR3
- EC2.7.10.1
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P35916#ReceptorforVEGFC.Hasatyrosine-proteinkinaseactivity. SIZE:1298aminoacids;145599Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Placenta,lung,heart,andkidney,doesnotseemtobeexpressedinpancreasandbrain. DISEASE:SwissProt:P35916#DefectsinFLT4arethecauseofhereditarylymphedemaI[MIM:153100];alsoknownasNonne-MilroylymphedemaorMilroydisease.Hereditarylymphedemaisachronicdisablingconditionwhichresultsinswellingoftheextremitiesduetoalteredlymphaticflow.Patientswithlymphedemasufferfromrecurrentlocalinfectionsandphysicalimpairment.HereditarylymphedemaIshowsautosomaldominantinheritanceandischaracterizedbyonsetusuallyatbirth.&DefectsinFLT4arefoundinjuvenilehemangioma.Juvenilehemangiomasarethemostcommontumorsofinfancy,occurringasmanyas10/%ofallbirths.Thesebenignvascularlesionsenlargerapidlyduringthefirstyearoflifebyhyperplasiaofendothelialcellsandattendantpericytes,andthenspontaneouslyinvoluteoveraperiodofyears,leavingloosefibrofattytissue. SIMILARITY:SwissProt:P35916##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.&Contains7Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |