Immunogen | SyntheticpeptidefromtheCOOHterminusoftheintracellulardomaincommontobothNF186andNF155. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | Neurofascin,commonepitope.ByWesternblottheantibodyrecognizesabandat~186kDainmousebrainlysate. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | NeurofascinisanL1familyimmunoglobulincelladhesionmolecule(seeL1CAM;MIM308840)involvedinaxonsubcellulartargetingandsynapseformationduringneuraldevelopment(Angoetal.,2004[PubMed15479642]).[suppliedbyOMIM] |
GeneSymbol | - NFASC
- OTTHUMP00000065315
- DKFZp686P2250
- FLJ46866
- OTTHUMP00000065305
- OTTHUMP00000065322
- KIAA0756
- OTTHUMP00000065324
- OTTHUMP00000065306
- OTTHUMP00000065307
- OTTHUMP00000065321
- NF
- neurofascin
- NRCAML
- OTTHUMP00000065308
- OTTHUMP00000065313
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:O94856#Celladhesion,ankyrin-bindingproteinwhichmaybeinvolvedinneuriteextension,axonalguidance,synaptogenesis,myelinationandneuron-glialcellinteractions(Bysimilarity). SIZE:1347aminoacids;150027Da SUBUNIT:Probableconstituentofaneurofascin/NRCAM/ankyrin-Gcomplex.Associateswiththesodiumchannelbeta-1(SCN1B)andbeta-3(SCN3B)subunits.InteractswithGLDN/gliomedin(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:O94856##Belongstotheimmunoglobulinsuperfamily.L1/neurofascin/NgCAMfamily.&Contains5fibronectintype-IIIdomains.&Contains6Ig-likeC2-type(immunoglobulin-like)domains. |
MolecularWeight | ~186kDa |