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Facade?-EM: Two Dimensional Amphiphile

3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane

Facade?-EM: Order the Latest Two-Dimensional Amphiphile

Facade?-EM (3α-hydroxy-7α,12α-di-((O-?-D-maltosyl)-2-hydroxyethoxy)-cholane) is a two-dimensional amphiphile with hydrophobic and hydrophilic faces. With its divergence from the traditional one-dimensional polar-head/nonpolar-tail molecules, this new class of detergents has a superior ability to stabilize integral membrane proteins. Keep reading to learn more.

How Do Detergents Relate to Protein Research?

One of the main challenges in protein biochemistry is the study of membrane proteins. This is especially true when working outside of the parameters of the natural lipid environment. When conducting in vitro studies, researchers rely heavily on the solubilization of membrane proteins—which typically requires wisely-chosen solubilizing detergents and mixed lipid/detergent systems.

The Application of Facade?EM

Facade?EM (3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane) may be used in several ways.

It can be used as a facial amphiphile detergent to purify protoxin-II (ProTx2)-voltage-sensor domain II (VSD2)-voltage-gated sodium (NavAb) channel. It can also be used as an additive in fluorescence quenching experiments of pentaene-SM 18, or to form isotropic bicelles with p75 for nuclear magnetic resonance (NMR) studies.

Purchase High-Quality Detergents from Avanti Polar Lipids

From unique detergents exclusive to Avanti to detergent kits and beyond, Avanti Polar Lipids has the products, services, and expertise you need to ensure the best results from your research—every time. Order Facade?EM here, or browse our entire catalog of detergents here.

Data

Hygroscopic

No

Light Sensitive

No

Molecular Formula

C₅₂H₉₀O₂₅

Percent Composition

C 56.00%, H 8.13%, O 35.86%

Purity

>99%

Stability

1 Years

Storage Temperature

-20°C

CAS Number

1429405-95-7 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

1115.256

Exact Mass

1114.577

Synonyms

FA-33α-hydroxy-7α,12α-di-((O-?-D-maltopyranosyl)ethyloxy)-cholane

Downloads

ChemDraw File
3D Structure
Structure
Technical Data Sheet
Safety Data Sheet

References

Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17.

PubMed ID: 30661758

Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201.

PubMed ID: 29720648

Lee, S.C., B.C. Bennett, W.X. Hong, Y. Fu, K.A. Baker, J. Marcoux, C.V. Robinson, A.B. Ward, J.R. Halpert, R.C. Stevens, C.D. Stout, M.J. Yeager, and Q. Zhang. (2013). Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proc Natl Acad Sci U S A 110:E1203-11. [PubMed]

PubMed ID: 23479627

Zhang, Q., X. Ma, A. Ward, W.X. Hong, V.P. Jaakola, R.C. Stevens, M.G. Finn, and G. Chang. (2007) Designing facial amphiphiles for the stabilization of integral membrane proteins. Angew Chem Int Ed Engl 46:7023-5. [PubMed]

PubMed ID: 17691085

Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.

PubMed ID: 29486112