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Millipore/09-849 | Anti-dimethyl MBP (Arg107) Antibody/09-849/100 µL
  • Millipore/09-849 | Anti-dimethyl MBP (Arg107) Antibody/09-849/100 µL

Millipore/09-849 | Anti-dimethyl MBP (Arg107) Antibody/09-849/100 µL

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貨號(hào): 09-849
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    • Description
      CatalogueNumber09-849
      DescriptionAnti-dimethylMBP(Arg107)Antibody
      AlternateNames
      • myelinbasicprotein
      • Golli-mbp
      • Myelinmembraneencephalitogenicprotein
      • MyelinA1protein,MBP
      BackgroundInformationMyelinbasicprotein(MBP)isthemajorextrinsicmembraneproteinofcentralnervoussystem.MBPisbelievedtobeimportantintheprocessofmyelinationofnervesinthecentralnervoussystem(CNS).MBPwasinitiallysequencedin1979afterisolationfrommyelinmembranes.Sincethattime,knockoutmicedeficientinMBPhavebeendevelopedwhichshoweddecreasedamountsofCNSmyelinationandaprogressivedisordercharacterizedbytremors,seizures,andearlydeath.ThegeneforMBPisonchromosome18;theproteinlocalizestotheCNSandtovariouscellsofthehematopoieticsystem.ThepoolofMBPinthecentralnervoussystemisverydiverse.NotonlyisMBPpresentinanumberofsplicevarients,buttheproteinalsoundergoesavarietyofpost-translationalmodifications,andexistsintheCNSinanumberofforms(i.e.phosphorylated,methylated,deamidatedandcitrullinated).
      InterestinMBPhascenteredonitsroleindemyelinatingdiseases,particularlymultiplesclerosis(MS).SeveralstudieshaveshownaroleforantibodiesagainstMBPinthepathogenesisofMS.SomestudieshavelinkedageneticpredispositiontoMStotheMBPgene,thoughamajorityhavenot.
      ProductInformation
      FormatSerum
      Control
      • mouseMBPknockoutandwildtypethymuslysates
      PresentationUnpurifiedrabbitpolyclonalinserumcontaining0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-dimethylMBP(Arg107)AntibodyisanantibodyagainstdimethylMBP(Arg107)foruseinWB.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheC-terminusofMBPdimethylatedatArg107.
      EpitopeMBPdimethylatedatArg107
      HostRabbit
      SpecificityThisantibodyrecognizesMBPdimethylatedatArg107.
      IsotypeIgG
      SpeciesReactivity
      • Mouse
      • Human
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithmouse.Predictedtoreactwithhumanandratbasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes.[providedbyRefSeq].
      GeneSymbol
      • MBP
      • multiplesclerosis
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.TheyhavearoleinbothitsformationandstABIlization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.

      SIZE:304aminoacids;33117Da

      SUBUNIT:Homodimer;isoform3existsasahomodimer.

      SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.

      TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.

      PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.

      DISEASE:Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).

      SIMILARITY:Belongstothemyelinbasicproteinfamily.
      MolecularWeightCalculatedat33kDa,themolecularweightofMBPwillvaryaccordingtospecificspliceisoformsandmodificationstates.DimethylatedMBPisobservedhereat17,20and28kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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