Immunogen | KLHconjugatedsyntheticpeptidecorrespondingtoaminoacidssurroundingTyr284ofhumanACK1. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesACK1phosphorylatedonTyrosineresidue284. |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneencodesatyrosinekinasethatbindsCdc42HsinitsGTP-boundformandinhibitsboththeintrinsicandGTPase-activatingprotein(GAP)-stimulatedGTPaseactivityofCdc42Hs.Thisbindingismediatedbyauniquesequenceof47aminoacidsC-terminaltoanSH3domain.TheproteinmaybeinvolvedinaregulatorymechanismthatsustainstheGTP-boundactiveformofCdc42Hsandwhichisdirectlylinkedtoatyrosinephosphorylationsignaltransductionpathway.Severalalternativelysplicedtranscriptvariantshavebeenidentifiedfromthisgene,butthefull-lengthnatureofonlytwotranscriptvariantshasbeendetermined. |
GeneSymbol | - TNK2
- p21cdc42Hs
- ACK1
- ACK-1
- FLJ45547
- FLJ44758
- ACK
|
Modifications | |
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q07912#DownstreameffectorofCDC42whichmediatesCDC42-dependentcellmigrationviaphosphorylationofBCAR1.Bindstobothpoly-andmono-ubiquitinandregulatesligand-induceddegradationofEGFR.Participatesinclathrin-mediatedendocytosis.Maybeinvolvedbothinadultsynapticfunctionandplasticityandinbraindevelopment. COFACTOR:Magnesium. SIZE:1036aminoacids;114327Da SUBUNIT:InteractswithCDC42.InteractswithactivatedCSPG4. SUBCELLULARLOCATION:Cellmembrane(Bysimilarity). SIMILARITY:SwissProt:Q07912##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.&Contains1CRIBdomain.&Contains1proteinkinasedomain.&Contains1SH3domain. |
MolecularWeight | 114kDa |