BackgroundInformation | Histonemethylationisinvolvedinmanykeyepigeneticphenomena,includingmaintainingtheboundariesbetweenheterochromatinandeuchromatin.Histonemethylationoflysinesisgenerallyassociatedwithtranscriptionalrepression,however,somemodifications,suchasmethylationofLys4ofhistoneH3,areassociatedwithtranscriptionalactivation.AcetylLys5ofhistoneH2Bhasbeenidentifiedinseveralsystems,whiletheroleofmethylationofLys5ofHistone2Bisunknown. |