Immunogen | SyntheticpeptidecorrespondingtoaninternalaminoacidsequenceofhumanWAVE1.Immunogensequenceisconservedinratandmouse. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | ThisantibodyrecognizesaninternalaminoacidsequenceofWAVE-1. |
SpeciesReactivity | |
SpeciesReactivityNote | Reactswithmouseandhuman.Reactivitywithotherspecieshasnotbeendetermined. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgene,amemberoftheWiskott-Aldrichsyndromeprotein(WASP)-family,playsacriticalroledownstreamofRac,aRho-familysmallGTPase,inregulatingtheactincytoskeletonrequiredformembraneruffling.IthasbeenshowntoassociatewithanactinnucleationcoreArp2/3complexwhileenhancingactinpolymerizationinvitro.Wiskott-Aldrichsyndromeisadiseaseoftheimmunesystem,likelyduetodefectsinregulationofactincytoskeleton.Multiplealternativelysplicedtranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene. |
GeneSymbol | - KIAA0269
- OTTHUMP00000016990
- SCAR1
- WAVE
- WAVE1
- FLJ31482
|
PurificationMethod | AffinityPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:DownstreameffectormoleculesinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactincytoskeleton. SUBUNITSTRUCTURE:ComponentoftheWAVE1complexcomposedofABI2,CYFIP2,C3orf10/HSPC300,NCKAP1andWASF1/WAVE1.CYFIP2bindstoactivatedRAC1whichcausesthecomplextodissociate,releasingactivatedWASF1.ThecomplexcanalsobeactivatedbyNCK1Bysimilarity.BindsactinandtheArp2/3complex.InteractswithBAIAP2. SUBCELLULARLOCATIION:Cytoplasm?cytoskeleton.Note:Dot-likepatterninthecytoplasm.ConcentratedinRac-regulatedmembrane-rufflingareas. TISSUESPECIFICITY:Highlyexpressedinbrain.Lowlyexpressedintestis,ovary,colon,kidney,pancreas,thymus,smallintestineandperipheralblood. DOMAIN:BindstheArp2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain. SEQUENCESIMILARITIES:BelongstotheSCAR/WAVEfamily. Contains1WH2domain. |
MolecularWeight | Approx.62kDa |