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Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL
  • Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL

Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL

價格: ￥5052.00 市場價: 8420.00
貨號: 07-131
品牌: Millipore
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    • Description
      CatalogueNumber07-131
      Replaces05-707
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-Sirt1(Sir2)Antibody
      AlternateNames
      • SIR2-likeprotein2
      • silencinginformationregulator2-like
      • silentinformationregulator2
      • sir2-relatedproteintype2
      • sirtuin(silentmatingtypeinformationregulation2homolog)2(S.cerevisiae)
      • sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae
      • homolog)2
      • sirtuin2
      • sirtuintype2
      BackgroundInformationSirtuinsareafamilyofcloselyrelatedenzymesnamedaftertheyeastgeneSir2(silentmatingtypeinformationregulation2).MembersoftheSirtuinfamilyhavebeenfoundinnearlyallorganismsstudied.Sirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Sirtuinshavebeenimplicatedintheregulationofaging,transcription,apoptosisandstressresistance.Sirt1(alsoknownasSirtuin1,Sir2L1,andSir2a),themammalianhomologofyeastSir2,hasbeenshowntodeacetylateandtherebydeactivatethep53proteintoregulatecellularprocesses.
      ProductInformation
      FormatAffinityPurified
      Control
      • Jurkatcelllysate,humancoloncarcinomaorhumanlungsquamouscarcinoma.
      PresentationPurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%sodiumazideand30%gylcerol
      StorageandShippingInformation
      StorageConditions1yearat-20°Cfromdateofshipment.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.
      Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationUseAnti-Sirt1(Sir2)Antibody(RabbitPolyclonalAntibody)ispublished(morethan30citations)andvalidatedinICC,IP,WBtodetectSirt1(Sir2)alsoknownasSilencinginformationregulator2-like,sirtuin2.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesImmunoprecipitation:
      5μLofapreviouslotofthisantibodyhasbeenshowntoimmunoprecipitateSirt1from1mgofa3T3/A31RIPAcellextract.

      Immunocytochemistry:
      ThisantibodyhasbeenreportedtodetectSirt1in3T3cellsfixedwithparaformaldehyde.

      ChromatinImmunoprecipitation:
      PublishedbyTiberietal.,(2012)
      BIOLOGicalInformation
      ImmunogenGST-taggedfusionproteincorrespondingtoaminoacids1-131ofmouseSir2α.
      Epitopea.a.1-131
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesSirt1.
      IsotypeIgG
      SpeciesReactivity
      • Mouse
      • Human
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twotranscriptvariantsresultfromalternativesplicingofthisgene.
      GeneSymbol
      • SIR2L1
      • SIR2alpha
      • hSIR2
      • hSIRT1
      PurificationMethodImmunoaffinityChromatography
      UniProtNumber
      UniProtSummaryFUNCTION:NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Essentialduringembryogenesisandgametogenesis.Deacetylates"Lys-382"ofp53/TP53andimpairsitsabilitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo.
      CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.
      COFACTOR:Binds1zincionpersubunit(Bysimilarity).
      ENZYMEREGULATION:Activatedbyresveratrol(3,5,4"-trihydroxy-trans-stilbene),butein(3,4,2",4"-tetrahydroxychalcone),piceatannol(3,5,3",4"-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2",4"-trihydroxychalcone),fisetin(3,7,3",4"-tetrahydroxyflavone)andquercetin(3,5,7,3",4"-pentahydroxyflavone)(Bysimilarity).Inhibitedbynicotinamide.
      SUBUNIT:InteractswithMLLT7/FOXO4,HES1,HEY2andPML(Bysimilarity).FoundinacomplexwithPCAFandMYOD1.Interactswithp53/TP53.InteractswithTAF1B.
      SUBCELLULARLOCATION:Nucleus(Bysimilarity).Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML(Bysimilarity).
      TISSUESPECIFICITY:Widelyexpressed.Weaklyexpressedinliverandskeletalmuscle.
      SIMILARITY:Belongstothesirtuinfamily.
      SIMILARITY:Contains1deacetylasesirtuin-typedomain.
      MolecularWeight110kDa;Uncharacterizedbands70and50observedinsomeLysates.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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