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Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg
  • Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg

Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg

價(jià)格: ￥4680.00 市場價(jià): 7800.00
貨號: 06-720
品牌: Millipore
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    • Description
      CatalogueNumber06-720
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-HDAC1Antibody
      AlternateNames
      • histonedeacetylase1,reducedpotassiumdependency,yeasthomolog-like1
      BackgroundInformationMammalianHADC1(alsodesignatedHD1),HDAC2(alsodesignatedmammalianRPD3)andHDAC3,allarerelatedtotheyeasttranscriptionalregulatorRpd3p,areidentifiedashistonedeacetylases.Thedeacetylationofhistonesisassociatedwithtranscriptionalsilencing.
      ProductInformation
      FormatPurified
      Control
      • NIH/3T3cellextract
        IncludedPositiveAntigenControl:Catalog#12-305,3T3/A31CellLysate.Add2.5μLof2-mercaptoethanolper100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedrabbitpolyclonalIgGinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaCl,containing0.05%sodiumazide.Frozenat-20oC.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.

      HandlingRecommendations:
      Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationUseAnti-HDAC1Antibody(RabbitPolyclonalAntibody)validatedinEA,ICC,IP,WBtodetectHDAC1alsoknownashistonedeacetylase1.
      KeyApplications
      • EnzymeAssays
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      5μgofapreviouslotimmunoprecipitatedHDAC1from500μgof3T3/A31RIPAlysate.

      Immunocytochemistry:
      ThisantibodyhasbeenreportedtoimmunostainHDAC1in1%paraformaldehydefixed,0.1%TritonX-100permeABIlized3T3cells.

      HDACActivity:
      ThisantibodyhasbeenreportedtoimmunoprecipitateactiveHDAC.
      BIOLOGicalInformation
      Immunogen6X-His-taggedfragmentrepresentingaminoacids53-482ofmousehistonedeacetylase1(HDAC1).
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesandisspecificforHDAC1,Mr65kDa.Maydetectsanon-specificproteinat~35kDa.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Rat
      • Mouse
      SpeciesReactivityNoteMouse,ratandhuman.Otherspeciescross-reactivitynottested.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistoneacetylationanddeacetylation,catalyzedbymultisubunitcomplexes,playakeyroleintheregulationofeukaryoticgeneexpression.Theproteinencodedbythisgenebelongstothehistonedeacetylase/acuc/aphafamilyandisacomponentofthehistonedeacetylasecomplex.Italsointeractswithretinoblastomatumor-suppressorproteinandthiscomplexisakeyelementinthecontrolofcellproliferationanddifferentiation.Togetherwithmetastasis-associatedprotein-2,itdeacetylatesp53andmodulatesitseffectoncellgrowthandapoptosis.[providedbyRefSeq]
      GeneSymbol
      • HDAC1
      • DKFZp686H12203
      • HD1
      • RPD3L1
      • GON-10
      • RPD3
      PurificationMethodProteinAchromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q13547#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.
      SIZE:482aminoacids;55103Da
      SUBUNIT:Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.Associateswiththe9-1-1complex;interactswithHUS1.FoundinacomplexwithDNMT3AandHDAC7.InteractswithBCOR,BRMS1L,DAXX,DNMT1,EP300,HCFC1,PCAF,PHB2,MIER1,JMJD2A/JHDM3A,MINT,NRIP1,RERE,SETDB1,SUV39H1,TGIF,TGIF2,UHRF1andUHRF2.Interactswiththenon-histoneregionofH2AFY.InteractswithHDAC9.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithBANP,CBFA2T3andJARID1B.InteractswithSAP30L.
      SUBCELLULARLOCATION:Nucleus.
      TISSUESPECIFICITY:Ubiquitous,withhigherlevelsinheart,pancreasandtestis,andlowerlevelsinkidneyandbrain.
      PTM:SumoylatedonLys-444andLys-476;whichpromotesenzymaticactivity.DesumoylatedbySENP1.&PhosphorylationonSer-421andSer-423promotesenzymaticactivityandinteractionswithNuRDandSIN3complexes.
      SIMILARITY:SwissProt:Q13547##Belongstothehistonedeacetylasefamily.Type1subfamily.
      MolecularWeight65kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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