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Millipore/06-503 | Anti-Caspase 1 Antibody/06-503/200 µg
  • Millipore/06-503 | Anti-Caspase 1 Antibody/06-503/200 µg

Millipore/06-503 | Anti-Caspase 1 Antibody/06-503/200 µg

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貨號(hào): 06-503
品牌: Millipore
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    • Description
      CatalogueNumber06-503
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-Caspase1Antibody
      AlternateNames
      • CASP1nirsvariant1
      • IL-1beta-convertingenzyme
      • Interleukin-1betaconvertase
      • Interleukin-1beta-convertingenzyme
      • caspase1
      • apoptosis-relatedcysteinepeptidase(interleukin1,betaconvertase)
      • apoptosis-relatedcysteineprotease(interleukin1
      • beta,convertase)
      • interleukin1-Bconvertingenzyme
      • interleukin1-betaconvertase
      BackgroundInformationCaspase-1,alsoknownasIL-1beta-convertingenzyme(ICE),isanezymethatcleavestheinflammatorycytokinesIL-1betaandIL-18,releasingthemature,activepeptides.Caspase-1isimportantfordefenseagainstpathogensanditalsoisinvolvedintheinductionofapoptosis.Thymocytesfromcaspase-1deficientmiceareresistanttoFas-mediatedapoptosis,andcaspase-1issimilartothecelldeathgeneCED-3ofC.elegans.Caspase-1isaheterotetramerthatconsistsoftwoanti-parallelheterodimers,eachoneformedbya20kDa(p20)anda10kDa(p10)subunit.TheenzymehasapreferredcleavagesiteofTyr-Val-Ala-Asp(YVAD).Caspase-1ishighlyexpressedinspleenandlung,andisabsentfrombrain.
      ProductInformation
      FormatPurified
      Control
      • HumanHL-60
      PresentationPurifiedrabbitIgGinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaClcontaining0.05%sodiumazide.Frozensolution.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.

      HandlingRecommendations:
      Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerol-containingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationAnti-Caspase1AntibodyisanantibodyagainstCaspase1foruseinIC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      5μgofapreviouslotofthisantibodyimmunoprecipitatedp45proenzymeformofCaspase1from500μgofhumanHL-60celllysates.

      Immunocytochemistry:
      10μg/mLofapreviouslotofthisantibodygavepositiveimmunostainingofHL60cells.
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecorrespondingtoaminoacidresidues129-149ofhumanCaspase1(PEHKTSDSTFLVFMSHGIREG).
      Epitopea.a.129-149
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesthep45proenzyme,Mr45kDa,andthep20subunit,Mr20kDa,ofreducedhumanCaspase1isoforms.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Rat
      • Mouse
      SpeciesReactivityNoteHuman,Mouse,Rat.Reactivitywithotherspecieshasnotbeenconfirmed.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproduce2subunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisgenewasidentifiedbyitsabilitytoproteolyticallycleaveandactivatetheinactiveprecursorofinterleukin-1,acytokineinvolvedintheprocessessuchasinflammation,septicshock,andwoundhealing.Thisgenehasbeenshowntoinducecellapoptosisandmayfunctioninvariousdevelopmentalstages.StudiesofasimilargeneinmousesuggestaroleinthepathogenesisofHuntingtondisease.Alternativesplicingofthisgeneresultsinfivetranscriptvariantsencodingdistinctisoforms.
      GeneSymbol
      • CASP1
      • IL1BCE
      • P45
      • IL-1BC
      • IL1BC
      • p45
      • IL1B-convertase
      • CASP-1
      • ICE
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P29466#ThiolproteasethatcleavesIL-1betabetweenanAspandanAla,releasingthematurecytokinewhichisinvolvedinavarietyofinflammatoryprocesses.Importantfordefenseagainstpathogens.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Canalsopromoteapoptosis.
      SIZE:404aminoacids;45159Da
      SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda10kDa(p10)subunit.Thep20subunitcanalsoformaheterodimerwiththeepsilonisoformwhichthenhasaninhibitoryeffect.Maybeacomponentoftheinflammasome,aproteincomplexwhichalsoincludesPYCARD,CARD8andNALP2andwhosefunctionwouldbetheactivationofproinflammatorycaspases.
      SUBCELLULARLOCATION:Cytoplasm.
      TISSUESPECIFICITY:Expressedinlargeramountsinspleenandlung.Detectedinliver,heart,smallintestine,colon,thymus,prostate,skeletalmuscle,peripheralbloodleukocytes,kidneyandtestis.Noexpressioninthebrain.
      PTM:Thetwosubunitsarederivedfromtheprecursorsequencebyanautocatalyticmechanism.
      SIMILARITY:SwissProt:P29466##BelongstothepeptidaseC14family.&Contains1CARDdomain....hide?seemore?
      MolecularWeightProenzyme(45kDa)andp20subunit(20kDa)
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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