Immunogen | LinearpeptidecorrespondingtoArABIdopsisthalianaHistoneH4acetylatedatandaroundacetylatedLys12. |
Epitope | Lys12 |
Host | Rabbit |
Specificity | ThisantibodyrecognizesHistoneH4acetylatedinandaroundLys12. |
SpeciesReactivity | |
SpeciesReactivityNote | Demonstratedtoreactwithhuman,mouse,andrat.PredictedtoreactwithArabidopsisthaliana(higherplant)andDrosophilabasedon100%sequencehomology. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | - HIST1H4A
- H4/J
- HIST1H4F
- HIST1H4L
- H4FN
- H4FA
- H4FH
- HIST1H4H
- H4F2
- H4FM
- H4/A
- H4FK
- H4FG
- HIST2H4
- H4FB
- H4/K
- HIST1H4I
- H4/N
- HIST1H4B
- H4FE
- H4/M
- H4/a
- HIST1H4E
- HIST4H4
- HIST2H4A
- H4FC
- H4FI
- H4/H
- HIST1H4C
- H4/G
- HIST1H4K
- H4FJ
- H4FD
- H4/I
- H4/B
- H4/D
- H4/C
- HIST1H4J
- HIST1H4D
- H4/E
|
Modifications | |
PurificationMethod | Unpurified |
UniProtNumber | |
UniProtSummary | FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
SUBCELLULARLOCATION:NucleusBysimilarity.
SEQUENCESIMILARITIES:BelongstothehistoneH4family. |
MolecularWeight | ~14kDa |